4.6.1.14: glycosylphosphatidylinositol diacylglycerol-lyase

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For detailed information about glycosylphosphatidylinositol diacylglycerol-lyase, go to the full flat file.

Word Map on EC 4.6.1.14

4.6.1.14

trypanosoma

brucei

glycosylphosphatidylinositols

gpi-anchored

procyclic

glycosylphosphatidylinositol-anchored

tsetse

gpi-deficient

medicine

anti-crd

stumpy

gpi-specific

Reaction

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate

Synonyms

(glycosyl)phosphatidylinositol-specific phospholipase C, EC 3.1.4.47, GDE3, glycan-phosphatidylinositol-specific phospholipase C, glycosyl inositol phospholipid anchor-hydrolyzing enzyme, glycosylphosphatidylinositol phospholipase C, glycosylphosphatidylinositol-phospholipase C, glycosylphosphatidylinositol-specific phospholipase C, glycosylphosphatidylinositol-specific phospholipase D, GPI-PC, GPI-phosphatidylinositol-phospholipase C, GPI-phospholipase C, GPI-phospholipase C polypeptide, GPI-PLC, GPI-PLC enzyme, GPI-PLCp, GPI-PLD, GPI-specific phospholipase C, phospholipase C, glycosylphosphatidylinositol, variant-surface-glycoprotein phospholipase C, variant-surface-glycoprotein-1,2-didecanoyl-sn-phosphatidylinositol inositolphosphohydrolase, VSG-lipase

ECTree

4 Lyases

4.6 Phosphorus-oxygen lyases

4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

4.6.1.14 glycosylphosphatidylinositol diacylglycerol-lyase

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Results	in table
15	Activating Compound
22	AA Sequence
3	Application
1	CAS Registry Number
10	Cloned(Commentary)
13	Disease/ Diagnostics
2	Expression
7	General Information
3	General Stability
53	Inhibitors
1	Ki Value [mM]
10	KM Value [mM]
20	Localization
5	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
64	Organism
5	pH Optimum
3	pH Range
2	Posttranslational Modification
58	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
37	Reference
14	Source Tissue
11	Specific Activity [micromol/min/mg]
3	Storage Stability
63	Substrates and Products (Substrate)
6	Subunits
48	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 4.6.1.14 - glycosylphosphatidylinositol diacylglycerol-lyase

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butanol

Mus musculus

activation, 2% v/v, acidic enzyme form, not neutral enzyme form

648768

deoxycholate

Mus musculus

activation, 0.5-1 mg/ml, neutral enzyme form, not acidic enzyme form, inhibits above 1 mg/ml

648768

dithiothreitol

Trypanosoma brucei

enzyme activity shows marked stimulation in the presence of the thiol-reducing agent, DTT

DTT

activation, 0.025 M

EDTA

activation, 5 mM

EGTA

glibenclamide

glimepiride

glimepiride M1

palmitate

Triton X-100

activation, above critical micelle concentration, inhibition from 0.05% to 0.5%

648770

additional information

3 entries