4.6.1.13: phosphatidylinositol diacylglycerol-lyase

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For detailed information about phosphatidylinositol diacylglycerol-lyase, go to the full flat file.

Reaction

Synonyms

1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming), 1-phosphatidylinositol phosphodiesterase, EC 3.1.4.10, monophosphatidylinositol phosphodiesterase, More, Phosphatidylinositol diacylglycerol-lyase, phosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, phosphatidylinositol-specific phospholipase C, phosphatidylinositol-specific PLC, phosphatidylinositolphospholipase C, PI-phospholipase C, PI-PLC, PLC, PLC1, PLC2, PLC3, PLC4, PLC5, PLC6

ECTree

     4 Lyases

         4.6 Phosphorus-oxygen lyases

             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

                4.6.1.13 phosphatidylinositol diacylglycerol-lyase

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Results	in table
35	Activating Compound
2774	AA Sequence
6	Application
2	CAS Registry Number
18	Cloned(Commentary)
8	Crystallization (Commentary)
4	Expression
10	General Information
1	General Stability
26	Inhibitors
4	Ki Value [mM]
9	KM Value [mM]
8	Localization
15	Metals/Ions
12	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
50	Organism
2	Pathway
27	PDB ID
14	pH Optimum
2	pH Range
1	pI Value
98	Protein Variants
20	Purification (Commentary)
7	Reaction
1	Reaction Type
47	Reference
2	Source Tissue
40	Specific Activity [micromol/min/mg]
1	Storage Stability
63	Substrates and Products (Substrate)
8	Subunits
57	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
2	Turnover Number [1/s]

pH Range

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pH Range on EC 4.6.1.13 - phosphatidylinositol diacylglycerol-lyase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

8

Bacillus thuringiensis

-

cleavage of phosphatidylinositol solubilized in diheptanoyl phosphatidylcholine, drop in activity around pH 8, consistent with the drop in binding affinity for activating surfaces

650231

additional information

Bacillus thuringiensis

-

pH-dependence study of wild-type and mutant PI-PLC

652552