4.6.1.13: phosphatidylinositol diacylglycerol-lyase
This is an abbreviated version!
For detailed information about phosphatidylinositol diacylglycerol-lyase, go to the full flat file.
Word Map on EC 4.6.1.13
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4.6.1.13
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11beta-hydroxysteroid
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cortisone
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phosphatidylcholine-specific
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11beta-hsd2
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pc-plc
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molecular biology
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analysis
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medicine
- 4.6.1.13
- 11beta-hydroxysteroid
- cortisone
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phosphatidylcholine-specific
- 11beta-hsd2
- pc-plc
- molecular biology
- analysis
- medicine
Reaction
Synonyms
1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming), 1-phosphatidylinositol phosphodiesterase, EC 3.1.4.10, monophosphatidylinositol phosphodiesterase, More, Phosphatidylinositol diacylglycerol-lyase, phosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, phosphatidylinositol-specific phospholipase C, phosphatidylinositol-specific PLC, phosphatidylinositolphospholipase C, PI-phospholipase C, PI-PLC, PLC, PLC1, PLC2, PLC3, PLC4, PLC5, PLC6
ECTree
4.6.1.13 phosphatidylinositol diacylglycerol-lyaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 4.6.1.13 - phosphatidylinositol diacylglycerol-lyase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-phosphatidyl-1D-myo-inositol
1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
1-phosphatidyl-1D-myo-inositol
1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
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?
1-phosphatidyl-1D-myo-inositol
1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
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?
1-phosphatidyl-1D-myo-inositol
1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
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?
1-phosphatidyl-1D-myo-inositol
1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol
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natural substrate
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?
1-phosphatidyl-1D-myo-inositol
1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol
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natural aggregate substrate, PI-PLC is a virulence factor of the animal and human pathogen
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additional information
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Bacillus anthracis enzyme down-modulates dendritic cell function und T cell responses, possibly by cleaving GPI-anchored proteins important for TLR-mediated dendritic cell activation
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additional information
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the enzyme may have a role in Bacillus anthracis pathogenesis
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additional information
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the enzyme exhibits cytotoxicity against some cultivated cells
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additional information
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Listeria monocytogenes phosphatidylinositol-specific phospholipase C is an important determinant of Listeria monocytogenes pathogenesis by absence of the Vb beta-strand, thus leading to greatly reduced activity on GPI-anchored proteins
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additional information
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the enzyme activates a host protein kinase C cascade which promotes escape of the bacterium from a macrophage-like cell phagosome
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additional information
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the enzyme contributes to listerial infection of epithelial cells and macrophages as a virulence factor cooperating with other factors such as listeriolysin O and phosphatidylcholine-preferring phospholipase C
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