4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

This is an abbreviated version!
For detailed information about 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, go to the full flat file.

Word Map on EC 4.6.1.12

4.6.1.12

electrolysis

salivary

mucoepidermoid

myoepithelial

milk

wastewater

anode

cathode

microvascular

adenoid

mastitis

geobacter

calponin

stat5

bioelectrochemical

caspofungin

coulomb

single-chamber

biocathode

electroactive

warthin

methanogenesis

posaconazole

syntrophic

echinocandins

voriconazole

micafungin

intermediate-grade

anidulafungin

bioanode

pnecs

biohydrogen

hydrogenotrophic

drug development

synthesis

analysis

medicine

Reaction

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate

Synonyms

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, 2-methylerythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase, cMEPP synthase, IspDF, IspE, IspF, MCS, MDS, ME-CPP synthase, MEC synthase, MECDP synthase, MECDP-synthase, MECP, MECPS, MECS, YGBB, YgbB protein

ECTree

4 Lyases

4.6 Phosphorus-oxygen lyases

4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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Results	in table
33706	AA Sequence
4	Application
1	CAS Registry Number
10	Cloned(Commentary)
12	Crystallization (Commentary)
7	Expression
4	General Information
78	IC50 Value
75	Inhibitors
4	KM Value [mM]
1	Localization
22	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
235	Organism
7	Pathway
217	PDB ID
2	pH Optimum
6	pI Value
2	Protein Variants
8	Purification (Commentary)
2	Reaction
2	Reaction Type
44	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
17	Subunits
54	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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Co2+

preferred

Mg2+

Mn2+

Na+

Shewanella oneidensis

presence of tetrahedral Zn2+ in one of the metal-binding sites and an octahedral sodium ion in the second metal site in absence of substrate

654130

Zinc

Escherichia coli

tightly binds one zinc ion per subunit of the trimer at the active site, which helps to position the substrate for direct attack of the 2-phosphate group on the beta-phosphate

656498

Zn2+

5 entries

additional information

Escherichia coli

P62617

the tetrahedrally arranged transition metal binding site, potentially occupied by Mn2+, sits at the base of the active site cleft. A phosphate oxygen of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate and the side chains of Asp8, His10, and His42 occupy the metal side chains of Asp8, His10, and His42 occupy the metal side coordination sphere

656112