4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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For detailed information about 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, go to the full flat file.

Reaction

Synonyms

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, 2-methylerythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase, cMEPP synthase, IspDF, IspE, IspF, MCS, MDS, ME-CPP synthase, MEC synthase, MECDP synthase, MECDP-synthase, MECP, MECPS, MECS, YGBB, YgbB protein

ECTree

     4 Lyases

         4.6 Phosphorus-oxygen lyases

             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

                4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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Results	in table
33706	AA Sequence
4	Application
1	CAS Registry Number
10	Cloned(Commentary)
12	Crystallization (Commentary)
7	Expression
4	General Information
78	IC50 Value
75	Inhibitors
4	KM Value [mM]
1	Localization
22	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
235	Organism
7	Pathway
217	PDB ID
2	pH Optimum
6	pI Value
2	Protein Variants
8	Purification (Commentary)
2	Reaction
2	Reaction Type
44	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
17	Subunits
54	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

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Application on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Plasmodium sp.

-

high-throughput method for the screening of 2C-methyl-D-erythritol synthase, IspC protein, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, IspD protein, 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, IspE protein, and 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, IspF protein, against large compound libraries

675583

drug development

Escherichia coli

P62617

framework for the development of IspF inhibitors to generate lead compounds of therapeutic potential against microbial pathogens

709435

medicine

Plasmodium falciparum

P62368

the enzyme is a potential target for antimalarial drugs directed at the nonmevalonate pathway of isoprenoid biosynthesis

655417

synthesis

Plasmodium sp.

-

preparation of 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate in multigram quantities

675583