4.5.1.2: 3-chloro-D-alanine dehydrochlorinase

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For detailed information about 3-chloro-D-alanine dehydrochlorinase, go to the full flat file.

Reaction

Synonyms

3-chloro-D-alanine chloride-lyase, beta-chloro-D-alanine dehydrochlorinase, DCyD

ECTree

     4 Lyases

         4.5 Carbon-halide lyases

             4.5.1 Carbon-halide lyases (only sub-subclass identified to date)

                4.5.1.2 3-chloro-D-alanine dehydrochlorinase

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1	CAS Registry Number
1	Cloned(Commentary)
4	Cofactor
4	Crystallization (Commentary)
2	General Information
23	Inhibitors
9	KM Value [mM]
6	Localization
6	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
46	Organism
5	pH Optimum
1	pH Range
1	pH Stability
7	Protein Variants
3	Purification (Commentary)
1	Reaction
12	Reaction Type
16	Reference
4	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
5	Subunits
3	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 4.5.1.2 - 3-chloro-D-alanine dehydrochlorinase

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SYSTEMATIC NAME

IUBMB Comments

3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)

A pyridoxal-phosphate protein. The enzyme cleaves a carbon-chlorine bond, releasing a chloride and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme's activity can also result in beta-replacement reactions, e.g. in the presence of hydrogen sulfide it can convert 3-chloro-D-alanine into D-cysteine and chloride.