4.5.1.1: DDT-dehydrochlorinase

This is an abbreviated version!
For detailed information about DDT-dehydrochlorinase, go to the full flat file.

Word Map on EC 4.5.1.1

4.5.1.1

hexachlorocyclohexane

dehydrochlorination

dehalogenase

lindane

dechlorinase

gamma-hexachlorocyclohexane

1,1,1-trichloro-2,2-bis-p-chlorophenylethane

haloalkane

nitroreductase

housefly

gamma-hch

biotechnology

2,6-dinitrotoluene

Reaction

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane

1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene

Synonyms

DDT dehydrochlorinase, DDT-ase, DDT-dehydrohalogenase, DDTase, dehydrochlorinase, GSTE2-2, GSTE5-5

ECTree

4 Lyases

4.5 Carbon-halide lyases

4.5.1 Carbon-halide lyases (only sub-subclass identified to date)

4.5.1.1 DDT-dehydrochlorinase

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Results	in table
6	Activating Compound
9	AA Sequence
3	Application
1	CAS Registry Number
1	Cloned(Commentary)
1	Cofactor
4	General Information
8	Inhibitors
2	KM Value [mM]
10	Metals/Ions
3	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
22	Organism
2	Pathway
2	pH Optimum
3	pH Stability
4	Posttranslational Modification
2	Purification (Commentary)
1	Reaction
1	Reaction Type
18	Reference
8	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
31	Substrates and Products (Substrate)
12	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.5.1.1 - DDT-dehydrochlorinase

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bromosulfophthalein

Ethacrynic acid

guanidine hydrochloride

Pseudomonas putida

complete inhibition at 1 M

714003

iodoacetate

Musca domestica

inhibition to a minor degree, completely reversible

34740

p-chloromercuribenzoate

Musca domestica

i.e. PCMB. 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane completely protects the fully aggregated enzyme against PCMB inhibition

34742

permethrin

Aedes aegypti

uncompetitive inhibitor of isoform GSTE2-2

715180

SDS

Pseudomonas putida

78% loss of activity at 5% (w/v)

714003

Urea

Pseudomonas putida

98% loss of activity at 10 mM

714003