4.4.1.5: lactoylglutathione lyase

This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.

Reaction

Synonyms

aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.5 lactoylglutathione lyase

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Results	in table
43	Activating Compound
16665	AA Sequence
23	Application
1	CAS Registry Number
55	Cloned(Commentary)
35	Cofactor
15	Crystallization (Commentary)
1045	Disease/ Diagnostics
25	Expression
41	General Information
1	General Stability
42	IC50 Value
326	Inhibitors
2	kcat/KM [mM/s]
63	Ki Value [mM]
143	KM Value [mM]
60	Localization
250	Metals/Ions
105	Molecular Weight [Da]
121	Natural Substrates/ Products (Substrates)
295	Organism
6	Pathway
75	PDB ID
27	pH Optimum
4	pH Range
2	pH Stability
17	pI Value
6	Posttranslational Modification
34	Protein Variants
62	Purification (Commentary)
17	Reaction
20	Reaction Type
269	Reference
186	Source Tissue
92	Specific Activity [micromol/min/mg]
5	Storage Stability
354	Substrates and Products (Substrate)
76	Subunits
337	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Stability [°C]
56	Turnover Number [1/s]

Synonyms

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Synonyms on EC 4.4.1.5 - lactoylglutathione lyase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

aldoketomutase

-

-

-

-

CLO GlxI

Clostridium acetobutylicum

Q97H22

-

729974

Glb33

Oryza sativa Japonica Group

Q948T6

-

652100

GLI

Mus musculus

-

ambiguous

708402

GLO I

Homo sapiens

Q04760

-

691217

GLO-1

Homo sapiens

-

-

708320, 709654, 714667

GLO-I

Homo sapiens

-

-

682254, 708034

Glo1

26 entries

GloA

17 entries

GloA1

2 entries

GloA2

2 entries

GloA3

2 entries

GloI

6 entries

Glx I

Homo sapiens

-

-

651571

Glx-I

2 entries

Glx1

Clostridium acetobutylicum

Q97H22

-

729974

GLXI

25 entries

Gly I

2 entries

gly-I

Homo sapiens

-

-

654009, 707837

GLY1

Brassica juncea

O04885

-

748643

glyoxalase 1

Homo sapiens

-

-

690438

glyoxalase I

55 entries

glyoxalase-1

3 entries

glyoxalase-I

2 entries

glyoxylase I

2 entries

GmGlyox I

Glycine max

Q9ZS21

-

649427

ketone-aldehyde mutase

-

-

-

-

lactoylglutathione lyase

Rattus norvegicus

-

-

690300

lactoylglutathione methylglyoxal lyase

9 entries

LGL

4 entries

lyase, lactoylglutathione

-

-

-

-

methylglyoxalase

-

-

-

-

methylglyoxylase

-

-

-

-

OsGLYI-11.2

Oryza sativa Japonica Group

Q948T6

-

730617

PfGlx I

Plasmodium falciparum

Q71KM3

-

651334

rhGLO I

Homo sapiens

Q04760

His-tagged GLO I protein

691217

S-D-lactoylglutathione methylglyoxal lyase

-

-

-

-

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

15 entries

S-D-lactoylglutathione:methylglyoxal lyase

2 entries

SpGlo1

Schizosaccharomyces pombe

-

-

663797

STM3117

2 entries

YaiA

2 entries

Glo1

Aeluropus lagopoides

-

-

709703

Glo1

Clostridium acetobutylicum

-

-

729177

Glo1

Escherichia coli

-

-

729177

Glo1

Homo sapiens

-

-

650721, 664268, 690438, 694142, 707868, 709339, 709815, 710151, 729175, 729176, 729177, 729179, 729369, 729392

Glo1

Homo sapiens

Q04760

-

681984, 710387, 748754

Glo1

Leishmania braziliensis

-

-

729176

Glo1

Leishmania donovani

-

-

729176, 729177

Glo1

Leishmania infantum

-

-

729176, 729177

Glo1

Leishmania infantum

Q2PYM9

-

706992

Glo1

Leishmania major

-

-

663550, 692329, 729176, 729177

Glo1

Leishmania major

Q68RJ8

-

666709, 681984

Glo1

Leishmania major Friedlin

-

-

-

Glo1

Mus musculus

-

-

708297, 708677, 709168, 709607, 710359, 710382, 729179

Glo1

Mus musculus

Q9CPU0

-

690774

Glo1

Neisseria meningitidis

-

-

729177

Glo1

Plasmodium falciparum

-

-

664268, 729176, 729177

Glo1

Pseudomonas aeruginosa

-

-

729177

Glo1

Pseudomonas fluorescens

-

-

729177

Glo1

Pseudomonas putida

-

-

729177

Glo1

Pseudomonas syringae

-

-

729177

Glo1

Saccharomyces cerevisiae

-

-

707439, 729177

Glo1

Saccharomyces cerevisiae YPH250

-

-

-

Glo1

Schizosaccharomyces pombe

-

-

663791

Glo1

Schizosaccharomyces pombe PR 109

-

-

-

Glo1

Trypanosoma cruzi

-

-

678043, 692329, 729176, 729177

Glo1

Yersinia pestis

-

-

729177

GloA

Clostridium acetobutylicum

-

-

729177

GloA

Escherichia coli

-

-

729177

GloA

Homo sapiens

-

-

729177

GloA

Leishmania donovani

-

-

729177

GloA

Leishmania infantum

-

-

729177

GloA

Leishmania major

-

-

729177

GloA

Neisseria meningitidis

-

-

729177

GloA

Plasmodium falciparum

-

-

729177

GloA

Pseudomonas aeruginosa

-

-

729177

GloA

Pseudomonas fluorescens

-

-

729177

GloA

Pseudomonas putida

-

-

729177

GloA

Pseudomonas syringae

-

-

729177

GloA

Saccharomyces cerevisiae

-

-

729177

GloA

Streptococcus pyogenes

-

-

748835

GloA

Streptococcus pyogenes M1T1

-

-

-

GloA

Trypanosoma cruzi

-

-

729177

GloA

Yersinia pestis

-

-

729177

GloA1

Pseudomonas aeruginosa

Q9HY85

-

692049

GloA1

Pseudomonas aeruginosa PAO1

Q9HU72

-

678463

GloA2

Pseudomonas aeruginosa

Q9I5L8

-

692049

GloA2

Pseudomonas aeruginosa PAO1

Q9HU72

-

678463

GloA3

Pseudomonas aeruginosa

Q9HU72

-

692049

GloA3

Pseudomonas aeruginosa PAO1

Q9HU72

-

678463

GloI

Homo sapiens

-

-

707602

GloI

Homo sapiens

Q04760

-

707749

GloI

Leishmania donovani

-

-

710372

GloI

Leishmania donovani

Q5XQR1

-

663884

GloI

Onchocerca volvulus

-

-

649699

GloI

Plasmodium falciparum

-

-

680821, 710003

Glx-I

Homo sapiens

-

-

709445

Glx-I

Saccharomyces cerevisiae

-

-

678641

GLXI

-

-

-

-

GLXI

Aeluropus lagopoides

-

-

709703

GLXI

Clostridium acetobutylicum

-

-

729177

GLXI

Escherichia coli

-

-

649769, 650003, 692049, 729177

GLXI

Escherichia coli

P0AC81

-

690917, 692049

GLXI

Homo sapiens

-

-

649441, 729177

GLXI

Homo sapiens

Q04760

-

692049

GLXI

Leishmania braziliensis

-

-

692049

GLXI

Leishmania donovani

-

-

692049, 729177

GLXI

Leishmania infantum

-

-

729177

GLXI

Leishmania major

-

-

692049, 729177

GLXI

Leishmania sp.

-

-

692049

GLXI

Neisseria meningitidis

-

-

663941, 729177

GLXI

Neisseria meningitidis

P0A0T3

-

692049

GLXI

Plasmodium falciparum

-

-

692049, 729177

GLXI

Pseudomonas aeruginosa

-

-

663941, 729177

GLXI

Pseudomonas aeruginosa

Q9HU72, Q9HY85, Q9I5L8

-

692049

GLXI

Pseudomonas aeruginosa PAO1

Q9HU72

-

678463

GLXI

Pseudomonas fluorescens

-

-

729177

GLXI

Pseudomonas putida

-

-

692049, 729177

GLXI

Pseudomonas putida

Q88GF8

-

692049

GLXI

Pseudomonas syringae

-

-

729177

GLXI

Saccharomyces cerevisiae

-

-

729177

GLXI

Trypanosoma cruzi

-

-

692049, 729177

GLXI

Yersinia pestis

-

-

663941, 692049, 729177

Gly I

Brassica juncea

-

-

694109

Gly I

Oryza sativa Japonica Group

Q948T6

-

730617

glyoxalase I

-

-

-

-

glyoxalase I

Aeluropus lagopoides

-

-

709703

glyoxalase I

Allium cepa

-

-

707782

glyoxalase I

Aloe vera

-

-

692050

glyoxalase I

Amaranthus sp.

-

-

692050

glyoxalase I

Bos taurus

-

-

653582, 653583

glyoxalase I

Brassica juncea

-

-

650298, 694109

glyoxalase I

Brassica juncea

O04885

-

653475, 653589

glyoxalase I

Brassica sp.

-

-

692050

glyoxalase I

Clostridium acetobutylicum

-

-

729177

glyoxalase I

Clostridium acetobutylicum

Q97H22

-

729974

glyoxalase I

Cyprinus carpio

-

-

691821

glyoxalase I

Escherichia coli

-

-

649441, 649769, 650003, 729177

glyoxalase I

Escherichia coli

P0AC81

-

690917, 692049

glyoxalase I

Glycine max

-

-

692050

glyoxalase I

Glycine max

Q9ZS21

-

649427

glyoxalase I

Homo sapiens

-

-

649441, 649677, 650721, 651571, 651577, 653583, 654009, 679014, 680638, 682102, 682254, 690442, 694142, 707014, 707602, 707837, 707868, 707962, 708320, 709339, 709445, 709654, 709815, 709820, 710567, 729175, 729176, 729177, 729179, 729369, 729392

glyoxalase I

Homo sapiens

Q04760

-

649874, 679014, 681984, 691217, 692049, 707749, 710387

glyoxalase I

Lactococcus lactis

Q9CJC0

-

692867

glyoxalase I

Lactococcus lactis IL1404

Q9CJC0

-

-

glyoxalase I

Leishmania braziliensis

-

-

729176

glyoxalase I

Leishmania donovani

-

-

710372, 729176, 729177

glyoxalase I

Leishmania infantum

-

-

729176, 729177

glyoxalase I

Leishmania infantum

Q2PYM9

-

706992

glyoxalase I

Leishmania major

-

-

692329, 729176, 729177

glyoxalase I

Leishmania major

Q68RJ8

-

681984

glyoxalase I

Leishmania major Friedlin

-

-

-

glyoxalase I

Leishmania sp.

-

-

692049

glyoxalase I

Mammalia

-

-

729178

glyoxalase I

Mus musculus

-

-

681891, 692048, 694250, 708297, 708402, 708677, 709168, 709607, 710359, 729179

glyoxalase I

Mus musculus

Q9CPU0

-

690774

glyoxalase I

Neisseria meningitidis

-

-

729177

glyoxalase I

Neisseria meningitidis

P0A0T3

-

692049

glyoxalase I

Nicotiana sp.

-

-

692050

glyoxalase I

Onchocerca volvulus

-

-

649699

glyoxalase I

Oryza sativa

-

-

692050, 710521

glyoxalase I

Oryza sativa Japonica Group

Q948T6

-

730617

glyoxalase I

Pisum sativum

-

-

692050

glyoxalase I

Plasmodium falciparum

-

-

680821, 692049, 710003, 729176, 729177

glyoxalase I

Plasmodium falciparum

Q71KM3

-

651334

glyoxalase I

Pseudomonas aeruginosa

-

-

729177

glyoxalase I

Pseudomonas aeruginosa

Q9HU72, Q9HY85, Q9I5L8

-

692049

glyoxalase I

Pseudomonas aeruginosa PAO1

Q9HU72

-

678463

glyoxalase I

Pseudomonas fluorescens

-

-

729177

glyoxalase I

Pseudomonas putida

-

-

690870, 729177

glyoxalase I

Pseudomonas putida

P16635

-

694000

glyoxalase I

Pseudomonas putida

Q88GF8

-

692049

glyoxalase I

Pseudomonas syringae

-

-

729177

glyoxalase I

Rattus norvegicus

-

-

690300, 692115

glyoxalase I

Saccharomyces cerevisiae

-

-

649441, 652123, 653582, 653583, 690845, 692804, 707439, 729177

glyoxalase I

Saccharomyces cerevisiae YPH250

-

-

-

glyoxalase I

Solanum tuberosum

-

-

692050

glyoxalase I

Triticum aestivum

-

-

692050, 709889

glyoxalase I

Trypanosoma cruzi

-

-

678043, 692329, 729176, 729177

glyoxalase I

Yersinia pestis

-

-

692049, 729177

glyoxalase-1

Caenorhabditis elegans

-

-

690310

glyoxalase-1

Homo sapiens

-

-

710151

glyoxalase-1

Mus musculus

-

-

710382

glyoxalase-I

Homo sapiens

-

-

708034

glyoxalase-I

Saccharomyces cerevisiae

-

-

678641, 678673

glyoxylase I

-

-

-

-

glyoxylase I

Arachis hypogaea

-

-

653438

lactoylglutathione methylglyoxal lyase

Aloe vera

-

-

692050

lactoylglutathione methylglyoxal lyase

Amaranthus sp.

-

-

692050

lactoylglutathione methylglyoxal lyase

Brassica sp.

-

-

692050

lactoylglutathione methylglyoxal lyase

Glycine max

-

-

692050

lactoylglutathione methylglyoxal lyase

Nicotiana sp.

-

-

692050

lactoylglutathione methylglyoxal lyase

Oryza sativa

-

-

692050

lactoylglutathione methylglyoxal lyase

Pisum sativum

-

-

692050

lactoylglutathione methylglyoxal lyase

Solanum tuberosum

-

-

692050

lactoylglutathione methylglyoxal lyase

Triticum aestivum

-

-

692050

LGL

Salmonella enterica subsp. enterica serovar Typhimurium

Q8ZM36

-

749417

LGL

Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720

Q8ZM36

-

-

LGL

Streptococcus mutans

-

-

680507

LGL

Streptococcus mutans UA159

-

-

-

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Clostridium acetobutylicum

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Escherichia coli

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Homo sapiens

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Leishmania donovani

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Leishmania infantum

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Leishmania major

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Neisseria meningitidis

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Plasmodium falciparum

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Pseudomonas aeruginosa

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Pseudomonas fluorescens

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Pseudomonas putida

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Pseudomonas syringae

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Saccharomyces cerevisiae

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Trypanosoma cruzi

-

-

729177

S-D-lactoylglutathione methylglyoxal lyase (isomerizing)

Yersinia pestis

-

-

729177

S-D-lactoylglutathione:methylglyoxal lyase

Saccharomyces cerevisiae

-

-

690845

S-D-lactoylglutathione:methylglyoxal lyase

Triticum aestivum

-

-

709889

STM3117

Salmonella enterica subsp. enterica serovar Typhimurium

Q8ZM36

-

749417

STM3117

Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720

Q8ZM36

-

-

YaiA

Lactococcus lactis

Q9CJC0

-

692867

YaiA

Lactococcus lactis IL1404

Q9CJC0

-

-