4.4.1.5: lactoylglutathione lyase

This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.

Reaction

Synonyms

aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.5 lactoylglutathione lyase

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Results	in table
43	Activating Compound
16665	AA Sequence
23	Application
1	CAS Registry Number
55	Cloned(Commentary)
35	Cofactor
15	Crystallization (Commentary)
1045	Disease/ Diagnostics
25	Expression
41	General Information
1	General Stability
42	IC50 Value
326	Inhibitors
2	kcat/KM [mM/s]
63	Ki Value [mM]
143	KM Value [mM]
60	Localization
250	Metals/Ions
105	Molecular Weight [Da]
121	Natural Substrates/ Products (Substrates)
295	Organism
6	Pathway
75	PDB ID
27	pH Optimum
4	pH Range
2	pH Stability
17	pI Value
6	Posttranslational Modification
34	Protein Variants
62	Purification (Commentary)
17	Reaction
20	Reaction Type
269	Reference
186	Source Tissue
92	Specific Activity [micromol/min/mg]
5	Storage Stability
354	Substrates and Products (Substrate)
76	Subunits
337	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Stability [°C]
56	Turnover Number [1/s]

Organism

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Organism on EC 4.4.1.5 - lactoylglutathione lyase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Aeluropus lagopoides

-

709703

-

-

brenda

Allium cepa

-

707782

-

-

brenda

Aloe vera

-

134193, 692050

-

-

brenda

Amaranthus sp.

-

692050

-

-

brenda

Anser sp.

-

37446

-

-

brenda

Arabidopsis sp.

-

37440

-

-

brenda

Arachis hypogaea

-

653438

-

-

brenda

Aspergillus niger

-

37414

-

-

brenda

Bos taurus

-

37446, 653582, 653583

-

-

brenda

Brassica juncea

7 entries

Brassica nigra

-

37440

-

-

brenda

Brassica oleracea

-

37440, 692050

-

-

brenda

Brassica rapa subsp. oleifera

-

37440

-

-

brenda

Brassica sp.

-

692050

-

-

brenda

Caenorhabditis elegans

-

690310

-

-

brenda

Cajanus cajan

-

37440

-

-

brenda

Candida albicans

-

37440

-

-

brenda

Canis lupus familiaris

-

37446

-

-

brenda

Cavia porcellus

-

37446

-

-

brenda

Chlamydomonas reinhardtii

5177D mt-

37443

-

-

brenda

Chlamydomonas reinhardtii 5177D mt-

5177D mt-

37443

-

-

brenda

Clostridium acetobutylicum

2 entries

Cyberlindnera mrakii

IFO 0895

37454

-

-

brenda

Cyprinus carpio

immature specimen

691821

-

-

brenda

Escherichia coli

6 entries

Escherichia coli MG1655/pGL10

MG1655/pGL10

37445

P0AC81

UniProt

brenda

Gallus gallus

-

37446

-

-

brenda

Glycine max

3 entries

Homo sapiens

21 entries

Hordeum vulgare

-

37440

-

-

brenda

Lactococcus lactis

IL1404

692867

Q9CJC0

UniProt

brenda

Lactococcus lactis IL1404

IL1404

692867

Q9CJC0

UniProt

brenda

Leishmania braziliensis

-

692049, 729176

-

-

brenda

Leishmania donovani

2 entries

Leishmania infantum

2 entries

Leishmania major

4 entries

Leishmania sp.

-

692049

-

-

brenda

Macaca mulatta

-

37446

-

-

brenda

Macaca radiata

-

37415

-

-

brenda

Mammalia

-

729178

-

-

brenda

Meleagris gallopavo

-

37446

-

-

brenda

Mus musculus

7 entries

Mytilus galloprovincialis

-

35018

-

-

brenda

Neisseria meningitidis

3 entries

Nicotiana sp.

-

692050

-

-

brenda

no activity in Entamoeba histolytica

-

729176

-

-

brenda

no activity in Giardia lamblia

-

729176

-

-

brenda

no activity in Trypanosoma brucei

2 entries

Onchocerca volvulus

causative agent of onchocerciasis, GloI expression is induced by oxidative stress

649699

-

-

brenda

Oryctolagus cuniculus

-

37413, 37424, 37446

-

-

brenda

Oryza sativa

2 entries

Oryza sativa Japonica Group

2 entries

Ovis aries

-

37413, 37429, 37446

-

-

brenda

Parastagonospora nodorum

-

664682

Q696X2

SwissProt

brenda

Parastagonospora nodorum SN15

-

664682

Q696X2

SwissProt

brenda

Pisum sativum

-

692050

-

-

brenda

Plasmodium falciparum

3 entries

Procambarus clarkii

crayfish, adult, female and male

691822

-

-

brenda

Pseudomonas aeruginosa

7 entries

Pseudomonas aeruginosa PAO1

-

678463

Q9HU72

Uniprot

brenda

Pseudomonas fluorescens

-

729177

-

-

brenda

Pseudomonas putida

4 entries

Pseudomonas syringae

-

729177

-

-

brenda

Rattus norvegicus

3 entries

Rhodospirillum rubrum

-

37413

-

-

brenda

Saccharomyces cerevisiae

4 entries

Saccharomyces cerevisiae DKD-5D-H

DKD-5D-H

37417

-

-

brenda

Saccharomyces cerevisiae YPH250

-

707439

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

-

749417

Q8ZM36

UniProt

brenda

Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720

-

749417

Q8ZM36

UniProt

brenda

Schizosaccharomyces pombe

2 entries

Schizosaccharomyces pombe PR 109

PR 109

663791

-

-

brenda

Solanum lycopersicum

-

37444, 692050

-

-

brenda

Solanum tuberosum

-

692050

-

-

brenda

Sorghum bicolor

-

37440

-

-

brenda

Starmerella magnoliae

-

715887

D6QLX5

UniProt

brenda

Streptococcus mutans

-

680507

-

-

brenda

Streptococcus mutans UA159

-

680507

-

-

brenda

Streptococcus pyogenes

-

748835

-

-

brenda

Streptococcus pyogenes M1T1

-

748835

-

-

brenda

Sus scrofa

-

37413, 37421, 37425, 37430, 37439, 37446

-

-

brenda

Triticum aestivum

4 entries

Trypanosoma cruzi

-

678043, 692049, 692329, 729176, 729177

-

-

brenda

Yersinia pestis

-

663941, 692049, 729177

-

-

brenda

Zea mays

-

37440

-

-

brenda

Brassica juncea

-

37440, 650298

-

-

brenda

Brassica juncea

-

653589

O04885

SwissProt

brenda

Brassica juncea

-

692050

-

-

brenda

Brassica juncea

-

748643

O04885

SwissProt

brenda

Brassica juncea

gene gly I coding for glyoxalase I transformed into Vigna mungo L. Hepper using Agrobacterium tumefaciens, controlled by a novel constitutive Cestrum yellow leaf curling viral promotor

694109

-

-

brenda

Brassica juncea

glyoxalase I expression is induced during salt stress

653475

O04885

SwissProt

brenda

Brassica juncea

no isoenzymes

37447

-

-

brenda

Clostridium acetobutylicum

-

729177

-

-

brenda

Clostridium acetobutylicum

gene clo glxI

729974

Q97H22

UniProt

brenda

Escherichia coli

-

37413, 37440, 649441, 649769, 650003

-

-

brenda

Escherichia coli

-

690917

P0AC81

UniProt

brenda

Escherichia coli

-

692049

-

-

brenda

Escherichia coli

-

692049

P0AC81

UniProt

brenda

Escherichia coli

-

729177

-

-

brenda

Escherichia coli

MG1655/pGL10

37445

P0AC81

UniProt

brenda

Glycine max

-

37456

-

-

brenda

Glycine max

soybean

649427

Q9ZS21

SwissProt

brenda

Glycine max

soybean

692050

-

-

brenda

Homo sapiens

-

37413, 37421, 37423, 37442, 37449, 37451, 37453, 649441, 649677

-

-

brenda

Homo sapiens

-

649874

Q04760

UniProt

brenda

Homo sapiens

-

650721, 651571, 651577, 653583, 654009, 664268, 679014

-

-

brenda

Homo sapiens

-

679014

Q04760

UniProt

brenda

Homo sapiens

-

680638

-

-

brenda

Homo sapiens

-

681984

Q04760

UniProt

brenda

Homo sapiens

-

682102, 682254, 690438

-

-

brenda

Homo sapiens

-

691217

Q04760

UniProt

brenda

Homo sapiens

-

692049

-

-

brenda

Homo sapiens

-

692049

Q04760

UniProt

brenda

Homo sapiens

-

694142, 694824, 707014, 707602

-

-

brenda

Homo sapiens

-

707749

Q04760

UniProt

brenda

Homo sapiens

-

707837, 707868, 707962, 708034, 708320, 709339, 709445, 709654, 709815, 709820, 710151

-

-

brenda

Homo sapiens

-

710387

Q04760

UniProt

brenda

Homo sapiens

-

710567, 714667, 729175, 729176, 729177, 729179, 729369, 729392

-

-

brenda

Homo sapiens

-

748754

Q04760

UniProt

brenda

Homo sapiens

3 isoenzymes

37419

-

-

brenda

Homo sapiens

caucasians

690442

-

-

brenda

Homo sapiens

expressed in bovine aortic endothelial cells

37457

-

-

brenda

Homo sapiens

isoform glyoxalase I

714437, 714438, 714457

-

-

brenda

Homo sapiens

two isoforms of glyoxalase I showing different electrophoretic properties result from a change in one amino acid residue at psotion 11 (Ala/Gln)

37448

-

-

brenda

Leishmania donovani

-

692049, 710372, 729176, 729177

-

-

brenda

Leishmania donovani

recombinant enzyme

663884

Q5XQR1

SwissProt

brenda

Leishmania infantum

-

706992

Q2PYM9

UniProt

brenda

Leishmania infantum

-

729176, 729177

-

-

brenda

Leishmania major

-

663550

-

-

brenda

Leishmania major

-

681984

Q68RJ8

SwissProt

brenda

Leishmania major

-

692049, 692329, 729176, 729177

-

-

brenda

Leishmania major

Friedlin A1 clone

666709

Q68RJ8

SwissProt

brenda

Mus musculus

-

37413, 37418, 37426, 37428, 37432, 37440, 37446

-

-

brenda

Mus musculus

-

690774

Q9CPU0

UniProt

brenda

Mus musculus

-

692048

-

-

brenda

Mus musculus

-

694865

Q9CPU0

UniProt

brenda

Mus musculus

-

708297, 708402, 708677, 709168, 709607, 710359, 710382, 729179

-

-

brenda

Mus musculus

Balb/c mice, C57BL6/J female mice

681891

-

-

brenda

Mus musculus

male Balb/cA, 3-4 week old

694250

-

-

brenda

Neisseria meningitidis

-

663941, 692049

-

-

brenda

Neisseria meningitidis

-

692049

P0A0T3

UniProt

brenda

Neisseria meningitidis

-

729177

-

-

brenda

no activity in Trypanosoma brucei

-

729176

-

-

brenda

no activity in Trypanosoma brucei

overexpression of glyoxalase I from Trypanosomas cruzi exhibits enzyme activity in Trypanosomas brucei. The wild-type Trypansoma brucei lacks the GLO1 activity. No apparent GLO1 gene can be identified in the genome

692329

-

-

brenda

Oryza sativa

-

692050

-

-

brenda

Oryza sativa

cultivar Pokkali

710521

-

-

brenda

Oryza sativa Japonica Group

L. Japonica

652100

Q948T6

UniProt

brenda

Oryza sativa Japonica Group

subsp. japonica, gene GLX-I or LOC_Os08g09250

730617

Q948T6

UniProt

brenda

Plasmodium falciparum

-

651334

Q71KM3

SwissProt

brenda

Plasmodium falciparum

-

680821, 692049, 710003, 729176, 729177

-

-

brenda

Plasmodium falciparum

active cytosolic glyoxalase 1, inactive glyoxalase 1-like protein

664268

-

-

brenda

Pseudomonas aeruginosa

-

663941

-

-

brenda

Pseudomonas aeruginosa

gloA1

692049

Q9HY85

UniProt

brenda

Pseudomonas aeruginosa

gloA2

692049

Q9I5L8

UniProt

brenda

Pseudomonas aeruginosa

gloA3

692049

Q9HU72

UniProt

brenda

Pseudomonas aeruginosa

PAO1

692049

-

-

brenda

Pseudomonas aeruginosa

PAO1

692049

Q9I5L8

UniProt

brenda

Pseudomonas aeruginosa

three isozymes of glyoxalase I

729177

-

-

brenda

Pseudomonas putida

-

37416, 37452, 690870, 692049

-

-

brenda

Pseudomonas putida

-

692049

Q88GF8

UniProt

brenda

Pseudomonas putida

-

694000

P16635

Uniprot

brenda

Pseudomonas putida

-

729177

-

-

brenda

Rattus norvegicus

-

37413, 37420, 37421, 37422, 37427, 37435, 37436, 37438, 690382, 690439

-

-

brenda

Rattus norvegicus

(SPF/VAF)-strain albino rats

690300

-

-

brenda

Rattus norvegicus

male albino rats

692115

-

-

brenda

Saccharomyces cerevisiae

-

37413, 37421, 37431, 37433, 37434, 37437, 37439, 37446, 37450, 37451, 37452, 37455, 649441, 652123, 653582, 653583, 678641, 678673, 707439, 729177

-

-

brenda

Saccharomyces cerevisiae

DKD-5D-H

37417

-

-

brenda

Saccharomyces cerevisiae

permeabilized with 0.01% (w/v) digitonin

690845

-

-

brenda

Saccharomyces cerevisiae

strains BY4741, null mutant DELTAglo1, and overexpressed strain YEpGLO1

692804

-

-

brenda

Schizosaccharomyces pombe

PR 109

663791

-

-

brenda

Schizosaccharomyces pombe

strains Pr109, JM544 and KS1366

663797

-

-

brenda

Triticum aestivum

-

37440, 692050

-

-

brenda

Triticum aestivum

cultivar Sumai 3

709889

-

-

brenda

Triticum aestivum

wheat

692050

-

-

brenda

Triticum aestivum

wheat bran

653552

Q9XGF2

Uniprot

brenda