4.4.1.5: lactoylglutathione lyase

This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.

Word Map on EC 4.4.1.5

4.4.1.5

glycation

detoxify

gsh

dicarbonyls

erythrocyte

d-lactate

adduct

dismutase

endproducts

rage

s-transferase

mellitus

methylglyoxal-induced

glyoxalases

byproduct

hyperglycemia

glutathione-dependent

phosphoglucomutase

metalloenzyme

hemithioacetal

mg-induced

hla-a

aldose

3-deoxyglucosone

enediolate

d-lactic

pentosidine

cyclopentyl

mdhar

haptoglobin

aminoguanidine

diesters

monodehydroascorbate

6-phosphogluconate

anti-glycation

dehydroascorbate

anxiety-like

gsh-dependent

pyridoxamine

analysis

trypanothione

medicine

drug development

Reaction

Synonyms

aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA

ECTree

4 Lyases

4.4 Carbon-sulfur lyases

4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

4.4.1.5 lactoylglutathione lyase

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Results	in table
43	Activating Compound
16665	AA Sequence
23	Application
1	CAS Registry Number
55	Cloned(Commentary)
35	Cofactor
15	Crystallization (Commentary)
1045	Disease/ Diagnostics
25	Expression
41	General Information
1	General Stability
42	IC50 Value
326	Inhibitors
2	kcat/KM [mM/s]
63	Ki Value [mM]
143	KM Value [mM]
60	Localization
250	Metals/Ions
105	Molecular Weight [Da]
121	Natural Substrates/ Products (Substrates)
295	Organism
6	Pathway
75	PDB ID
27	pH Optimum
4	pH Range
2	pH Stability
17	pI Value
6	Posttranslational Modification
34	Protein Variants
62	Purification (Commentary)
17	Reaction
20	Reaction Type
269	Reference
186	Source Tissue
92	Specific Activity [micromol/min/mg]
5	Storage Stability
354	Substrates and Products (Substrate)
76	Subunits
337	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Stability [°C]
56	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 4.4.1.5 - lactoylglutathione lyase

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14250

Pseudomonas aeruginosa

electrospray ionization mass spectrometry

663941

14251

Pseudomonas aeruginosa

x * 14251, electrospray ionization mass spectrometry, x * 14251, calculated

663941

14833

Yersinia pestis

x * 14833, electrospray ionization mass spectrometry, x * 14834, calculated

663941

148333

Yersinia pestis

2 * 148333, electrospray ionization mass spectrometry

663941

14834

Yersinia pestis

x * 14833, electrospray ionization mass spectrometry, x * 14834, calculated

663941

14919

Escherichia coli

P0AC81

2 * 14919, electrospray mass spectrometry

14990

2 * 14990, SDS-PAGE

15669

Neisseria meningitidis

x * 15669, electrospray ionization mass spectrometry, x * 15669, calculated

663941

15670

Neisseria meningitidis

electrospray ionization mass spectrometry

663941

15818

Clostridium acetobutylicum

Q97H22

2 * 15818, His6-tagged enzyme, sequence calculation, the enzyme forms two active sites, each within single subunits

16000

16607

2 * 16607, mass spectrometry

666709

16647

Trypanosoma cruzi

x * 17000, SDS-PAGE or Western blot analysis, x * 16647, predicted, x * 16650, MALDI-TOF-MS analysis

678043

16650

Trypanosoma cruzi

x * 17000, SDS-PAGE or Western blot analysis, x * 16647, predicted, x * 16650, MALDI-TOF-MS analysis

678043

17000

Trypanosoma cruzi

x * 17000, SDS-PAGE or Western blot analysis, x * 16647, predicted, x * 16650, MALDI-TOF-MS analysis

678043

18200

Leishmania infantum

Q2PYM9

2 * 18200, calculated from amino acid sequence

20000

1 * 20000, SDS-PAGE

20647

2 * 20647, sequence calculation, 2 * 21000, recombinant enzyme, SDS-PAGE

729392

20774

Homo sapiens

x * 20774, calculation from nucleotide sequence

37448

20810

Mus musculus

Q9CPU0

2 * 20810, calculated from sequence, MALDI-TOF mass spectrometry, SDS-PAGE

21000

21500

2 * 21500

22000

2 * 22000, SDS-PAGE

23000

23440

2 * 23440, SDS-PAGE

24000

25000

26000

27000

28000

Western blot analysis

694109

29000

2 entries

29670

Yersinia pestis

electrospray ionization mass spectrometry

30000

gel filtration

31000

Rhodospirillum rubrum

37413

31300

Trypanosoma cruzi

size exclusion chromatography and analytical ultracentrifugation

678043

32000

Saccharomyces cerevisiae

gel filtration

37421, 37434

32500

Triticum aestivum

calculated from amino acid sequence

709889

33000

3 entries

34000

2 entries

34900

Oryza sativa Japonica Group

Q948T6

recombinant enzyme, gel filtration

730617

35500

Starmerella magnoliae

D6QLX5

x * 35500, calculated

715887

35840

Plasmodium falciparum

calculated from amino acid sequence

36000

37000

38000

38700

gel filtration

41620

calculated from sequence, MALDI-TOF mass spectrometry

694865

42000

2 entries

42300

Plasmodium falciparum

gel filtration

43000

43310

calculated from sequence, 30fold upregulated protein spot in the 2D-electrophoresis, identified as glyoxalase I, the expression is regulated by the operon yahCD-yaiAB

692867

43600

Plasmodium falciparum

Q71KM3

1 * 43600, SDS-PAGE, recombinant His-tagged PfGlx I

44000

45000

gel filtration

45900

gel filtration

46000

48000

50000

liver and erythrocyte enzyme, gel filtration

51000

52000

gel filtration

54000

gel filtration

56000

gel filtration

58000

60000

additional information

8 entries