4.4.1.5: lactoylglutathione lyase
This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.
Word Map on EC 4.4.1.5
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4.4.1.5
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glycation
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detoxify
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gsh
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dicarbonyls
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erythrocyte
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d-lactate
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adduct
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dismutase
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endproducts
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rage
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s-transferase
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mellitus
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methylglyoxal-induced
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glyoxalases
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byproduct
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hyperglycemia
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glutathione-dependent
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phosphoglucomutase
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metalloenzyme
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hemithioacetal
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mg-induced
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hla-a
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aldose
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3-deoxyglucosone
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enediolate
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d-lactic
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pentosidine
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cyclopentyl
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mdhar
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haptoglobin
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aminoguanidine
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diesters
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monodehydroascorbate
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6-phosphogluconate
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anti-glycation
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dehydroascorbate
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anxiety-like
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gsh-dependent
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pyridoxamine
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analysis
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trypanothione
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medicine
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drug development
- 4.4.1.5
-
glycation
-
detoxify
- gsh
-
dicarbonyls
- erythrocyte
- d-lactate
- adduct
- dismutase
-
endproducts
- rage
- s-transferase
- mellitus
-
methylglyoxal-induced
-
glyoxalases
-
byproduct
- hyperglycemia
-
glutathione-dependent
- phosphoglucomutase
-
metalloenzyme
- hemithioacetal
-
mg-induced
- hla-a
- aldose
- 3-deoxyglucosone
-
enediolate
-
d-lactic
-
pentosidine
-
cyclopentyl
- mdhar
- haptoglobin
- aminoguanidine
- diesters
- monodehydroascorbate
- 6-phosphogluconate
-
anti-glycation
- dehydroascorbate
-
anxiety-like
-
gsh-dependent
- pyridoxamine
- analysis
- trypanothione
- medicine
- drug development
Reaction
Synonyms
aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA
ECTree
4.4.1.5 lactoylglutathione lyaseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 4.4.1.5 - lactoylglutathione lyase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
ascorbic acid
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enhances slightly glyoxalase I activity, dose-dependently 0-2 g/l, pH 6.6, 37°C
D-glucose
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25 mM upregulates glyoxalase I activity and mRNA in LE cells when compared with either cells cultured with 5 mM glucose as control or with 20 mM L-glucose + 5 mM D-glucose
light
Amaranthus sp.
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red and blue light exposure increases gly I activity in dark-gron Amaranthus sp. indicating expression of enzyme is under stringent regulation by photoreceptors in plants
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methylglyoxal
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addition at pH 5.0 results in a significant 98% increase in the glycolytic rate
S-ethyl cysteine
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enhances significantly glyoxalase I activity, dose-dependently 0-2 g/l, pH 6.6, 37°C
S-propyl-cysteine
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enhances significantly glyoxalase I activity, dose-dependently 0-2 g/l, pH 6.6, 37°C
additional information
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not only light but a number of other exogenous factors, such as hypoxia, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
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additional information
Amaranthus sp.
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not only light but a number of other exogenous factors, such as hypoxai, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
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additional information
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not only light but a number of other exogenous factors, such as hypoxia, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
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additional information
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the octahedral metal ligand geometry appears to be mechanistically quintessential to Glo1 enzymatic activity, regardless of the Glo1 metal-activation class
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additional information
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not only light but a number of other exogenous factors, such as hypoxia, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
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additional information
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glyoxalase I protein amounts are 1.5fold increased in early Alzheimers disease subjects
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additional information
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glyoxalase I is highly overexpressed in highly invasive tumors in comparison to tumors with low malignant potential
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additional information
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not only light but a number of other exogenous factors, such as hypoxia, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
-
additional information
-
not only light but a number of other exogenous factors, such as hypoxia, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
-
additional information
-
not only light but a number of other exogenous factors, such as hypoxia, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
-
additional information
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1.21 mg/kg crayfish, selenium-enriched diet, female crayfish, results in a tendency to an increased enzyme activity
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additional information
activity of glyoxalase I in transgenic Escherichia coli with Pseudomonas putida glyoxalase I under anaerobic conditions is 12fold higher than that in control cells
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additional information
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activity of glyoxalase I in transgenic Escherichia coli with Pseudomonas putida glyoxalase I under anaerobic conditions is 12fold higher than that in control cells
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additional information
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treatment of the dimer with glutathione yields an active monomer. The monomer is metastable and slowly reverts to the active dimer in the absence of glutathione
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additional information
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no change in glyoxalase I activity in taurine-treated rats, 2% (w/v)
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additional information
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enzyme acitivating in vivo: osmotic stress by sorbitol treatment, 0.9 M, 1 h. No increase in enzyme activity following sorbitol treatment when cycloheximide is present
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additional information
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not activating: incubation of purified enzyme with 0-300 mM glycerol in vitro
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additional information
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not only light but a number of other exogenous factors, such as hypoxia, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
-
additional information
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is up-regulated during acid challenge, is induced during acidic growth 3.5fold and following acid adaptation 2fold, is up-regulated approximately 7fold during the exponential growth phase compared with that in the stationary growth phase
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additional information
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not only light but a number of other exogenous factors, such as hypoxia, temperature shock, and water stress, transduce their signal through Ca2+ that binds specific target proteins, including kinases, which in turn can activate gly I
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