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4.4.1.4: alliin lyase

This is an abbreviated version!
For detailed information about alliin lyase, go to the full flat file.

Word Map on EC 4.4.1.4

Reaction

an S-alkyl-L-cysteine S-oxide
=
an alkyl sulfenate
+
2-aminoacrylate

Synonyms

alkylcysteine sulfoxide lyase, alkylsulphenate lyase, ALL1, alliin lyase, alliin-lyase, alliinase, alliinase I, alliinase II, allinase, C-S lyase, C-S-lyase, cys sulfoxide lyase, cysteine sulfoxide lyase, Cysteine sulphoxide lyase, L-(+)-S-alk(en)ylcysteine sulfoxide lyase, L-cysteine sulfoxide lyase, lyase, alliin, More, P-19486 alliinase, S-alkyl(en)yl-L-cysteine lyase, S-alkylcysteine sulfoxide lyase

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.4 alliin lyase

Inhibitors

Inhibitors on EC 4.4.1.4 - alliin lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Aminooxyacetate
-
-
Dicyclohexylcarbodiimide
-
-
DL-homocysteine
-
competitive
hydrazine
-
-
hydroxylamine
Iodine
-
-
iodoacetate
-
-
L-Cys
-
competitive
L-cysteine ethyl ester
-
competitive
N-acetyl-L-Cys
-
competitive
N-Acetylimidazole
-
slightly decreases activity
N-bromosuccinimide
-
rapidly and completely inactivates
Penicillamine
-
competitive inhibitor
petivericin
-
downstream thiosulfinate products petivericin (100 microM) and pyruvate (8.4 mM) inhibit alliinase activity by 60% and 29%, respectively, after 1 h, and a mixture of the two inhibits alliinase activity by 65%
Phenylmercury acetate
-
-
pyruvate
-
downstream thiosulfinate products petivericin (100 microM) and pyruvate (8.4 mM) inhibit alliinase activity by 60% and 29%, respectively, after 1 h, and a mixture of the two inhibits alliinase activity by 65%
rotenone
-
-
S-alkyl derivatives of L-Cys
-
competitive
S-allyl-L-Cys
-
competitive
S-ethyl-L-Cys
-
competitive
S-propyl-L-Cys
-
competitive
S-tert-butyl-L-Cys
-
competitive
Succinic anhydride
-
slightly decreases activity
Trinitrobenzenesulfonic acid
-
2.5 mM, 50% inhibition
additional information
-