4.4.1.28: L-cysteine desulfidase
This is an abbreviated version!
For detailed information about L-cysteine desulfidase, go to the full flat file.
Reaction
Synonyms
aecD, At5g28030, CDL, CFL1_01513, cystalysin, DES1, L-cysteine desulfhydrase, les, MJ1025
ECTree
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Systematic Name
Systematic Name on EC 4.4.1.28 - L-cysteine desulfidase
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L-cysteine sulfide-lyase (deaminating; pyruvate-forming)
The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster and is specific for L-cysteine (cf. EC 4.4.1.1, cystathionine gamma-lyase). It cleaves a carbon-sulfur bond releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The same reaction can also be catalysed by some pyridoxal-phosphate proteins (cf. EC 4.4.1.1, cystathionine gamma-lyase).