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4.4.1.28: L-cysteine desulfidase

This is an abbreviated version!
For detailed information about L-cysteine desulfidase, go to the full flat file.

Reaction

2-aminoprop-2-enoate
=
2-iminopropanoate

Synonyms

aecD, At5g28030, CDL, CFL1_01513, cystalysin, DES1, L-cysteine desulfhydrase, les, MJ1025

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.28 L-cysteine desulfidase

Systematic Name

Systematic Name on EC 4.4.1.28 - L-cysteine desulfidase

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SYSTEMATIC NAME
IUBMB Comments
L-cysteine sulfide-lyase (deaminating; pyruvate-forming)
The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster and is specific for L-cysteine (cf. EC 4.4.1.1, cystathionine gamma-lyase). It cleaves a carbon-sulfur bond releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The same reaction can also be catalysed by some pyridoxal-phosphate proteins (cf. EC 4.4.1.1, cystathionine gamma-lyase).