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4.4.1.28: L-cysteine desulfidase

This is an abbreviated version!
For detailed information about L-cysteine desulfidase, go to the full flat file.

Reaction

2-aminoprop-2-enoate
=
2-iminopropanoate

Synonyms

aecD, At5g28030, CDL, CFL1_01513, cystalysin, DES1, L-cysteine desulfhydrase, les, MJ1025

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.28 L-cysteine desulfidase

Inhibitors

Inhibitors on EC 4.4.1.28 - L-cysteine desulfidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cyanoborohydride
-
complete inactivation
dithiothreitol
-
0.5 mM
EDTA
7.1 mM, 70% inhibition
glycine
hydroxylamine
iodoacetamide
0.42 mM, half-life: 12 min. 17 mM, preincubation completely abolishes activity
L-alanine
L-asparagine
-
less effective inhibitor, Ki-value above 150 mM
L-methionine
-
less effective inhibitor, Ki-value above 150 mM
L-serine
-
-
L-threonine
-
less effective inhibitor, Ki-value above 150 mM
L-tryptophan
-
competitive inhibitor
L-valine
-
less effective inhibitor, Ki-value above 150 mM
N-ethylmaleimide
0.42 mM, half-life: 8 min
additional information
-
not inhibited by Nalpha-p-tosyl-L-lysine chloromethyl ketone, pronase, proteinase K, CaCl2, MgCl2, ZnCl2, PMSF or benzamidine
-