4.4.1.28: L-cysteine desulfidase

This is an abbreviated version!
For detailed information about L-cysteine desulfidase, go to the full flat file.

Reaction

Synonyms

aecD, At5g28030, CDL, CFL1_01513, cystalysin, DES1, L-cysteine desulfhydrase, les, MJ1025

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.28 L-cysteine desulfidase

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Results	in table
4	Activating Compound
43	AA Sequence
9	Cloned(Commentary)
4	Cofactor
2	Expression
14	General Information
19	Inhibitors
7	kcat/KM [mM/s]
4	Ki Value [mM]
18	KM Value [mM]
1	Localization
3	Metals/Ions
10	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
18	Organism
1	Oxidation Stability
3	Pathway
5	PDB ID
6	pH Optimum
2	pH Range
1	pI Value
22	Protein Variants
9	Purification (Commentary)
12	Reaction
18	Reference
5	Source Tissue
9	Specific Activity [micromol/min/mg]
1	Storage Stability
39	Substrates and Products (Substrate)
14	Subunits
22	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
8	Temperature Stability [°C]
14	Turnover Number [1/s]

Engineering

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Engineering on EC 4.4.1.28 - L-cysteine desulfidase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

C25A

Methanocaldococcus jannaschii

Q58431

mutation reduces the catalytic efficiency and thermal stability of the enzyme

726942

C282A

Methanocaldococcus jannaschii

Q58431

mutation reduces the catalytic efficiency and thermal stability of the enzyme

726942

C322S

Methanocaldococcus jannaschii

Q58431

mutation reduces the catalytic efficiency and thermal stability of the enzyme

726942

C329S

Methanocaldococcus jannaschii

Q58431

mutation reduces the catalytic efficiency and thermal stability of the enzyme

726942

C332A/C329A

Methanocaldococcus jannaschii

Q58431

complete loss of activity

726942

D323N

Methanocaldococcus jannaschii

Q58431

about 45% loss of specific activity

726942

H139N

Methanocaldococcus jannaschii

Q58431

about 10% loss of specific activity

726942

C25A

Methanocaldococcus jannaschii DSM 2661

-

mutation reduces the catalytic efficiency and thermal stability of the enzyme

-

C282A

Methanocaldococcus jannaschii DSM 2661

-

mutation reduces the catalytic efficiency and thermal stability of the enzyme

-

C322S

Methanocaldococcus jannaschii DSM 2661

-

mutation reduces the catalytic efficiency and thermal stability of the enzyme

-

C329S

Methanocaldococcus jannaschii DSM 2661

-

mutation reduces the catalytic efficiency and thermal stability of the enzyme

-

C332A/C329A

Methanocaldococcus jannaschii DSM 2661

-

complete loss of activity

-

D198N

Prevotella intermedia

B9X1L2

mutation resuklts in complete disappearance of the L-cysteine desulfhydrase activity

730535

K233N

Prevotella intermedia

B9X1L2

mutation resuklts in complete disappearance of the L-cysteine desulfhydrase activity

730535

R365G

Prevotella intermedia

B9X1L2

mutant enzyme retains catalytic activity as well as the wild-type enzyme

730535

Y118A

Prevotella intermedia

B9X1L2

mutation resuklts in complete disappearance of the L-cysteine desulfhydrase activity

730535

Y59A

Prevotella intermedia

B9X1L2

mutation resuklts in complete disappearance of the L-cysteine desulfhydrase activity

730535

D198N

Prevotella intermedia ATCC 25611

-

mutation resuklts in complete disappearance of the L-cysteine desulfhydrase activity

-

K233N

Prevotella intermedia ATCC 25611

-

mutation resuklts in complete disappearance of the L-cysteine desulfhydrase activity

-

R365G

Prevotella intermedia ATCC 25611

-

mutant enzyme retains catalytic activity as well as the wild-type enzyme

-

Y118A

Prevotella intermedia ATCC 25611

-

mutation resuklts in complete disappearance of the L-cysteine desulfhydrase activity

-

Y59A

Prevotella intermedia ATCC 25611

-

mutation resuklts in complete disappearance of the L-cysteine desulfhydrase activity

-