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4.4.1.23: 2-hydroxypropyl-CoM lyase

This is an abbreviated version!
For detailed information about 2-hydroxypropyl-CoM lyase, go to the full flat file.

Word Map on EC 4.4.1.23

Reaction

(R)-2-Hydroxypropyl-CoM
=
(R)-1,2-epoxypropane
 +
HS-CoM

Synonyms

coenzyme M-epoxyalkane ligase, Ea-CoMT, EaCoMT, EC 4.2.99.19, epoxyalkane coenzyme M transferase, epoxyalkane:2-mercaptoethanesulfonate transferase, epoxyalkane:CoM transferase, epoxyalkyl:CoM transferase, epoxypropane:coenzyme M transferase, epoxypropyl:CoM transferase, EtnE, transferase, epoxyalkyl:coenzyme M

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.23 2-hydroxypropyl-CoM lyase

Specific Activity

Specific Activity on EC 4.4.1.23 - 2-hydroxypropyl-CoM lyase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.039
wild-type enzyme, transferred to Mycobacterium smegmatis
0.056
mutation W243G, transferred to Mycobacterium smegmatis
0.062
mutation R257L, transferred to Mycobacterium smegmatis
0.074
wild-type enzyme
0.15
vinyl-chloride adapted variant JS623-E
0.645
vinyl-chloride adapted variant JS623-T
1.3
-
substrate ethylene oxide, 30°C
143
-
epoxypropane as substrate
3.4
-
substrate ethene, 30°C
3.5
-
substrate ethylene oxide, 30°C
3.7
-
substrate vinyl chloride, 30°C
4.4
-
substrate vinyl chloride, 30°C
4.6
-
substrate ethene, 30°C
615
-
epoxyethane as substrate