4.4.1.2: homocysteine desulfhydrase
This is an abbreviated version!
For detailed information about homocysteine desulfhydrase, go to the full flat file.
Reaction
Synonyms
desulfhydrase, homocysteine, homocysteine desulfurase, Hyc gamma-lyase
ECTree
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Systematic Name
Systematic Name on EC 4.4.1.2 - homocysteine desulfhydrase
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L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogen sulfide and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase