4.4.1.2: homocysteine desulfhydrase

This is an abbreviated version!
For detailed information about homocysteine desulfhydrase, go to the full flat file.

Reaction

Synonyms

desulfhydrase, homocysteine, homocysteine desulfurase, Hyc gamma-lyase

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.2 homocysteine desulfhydrase

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Results	in table
1	Activating Compound
141	AA Sequence
2	Application
1	CAS Registry Number
17	Inhibitors
4	KM Value [mM]
2	Localization
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
18	Organism
3	Pathway
41	PDB ID
2	pH Optimum
3	pH Stability
1	pI Value
4	Protein Variants
1	Purification (Commentary)
4	Reaction
1	Reaction Type
18	Reference
2	Specific Activity [micromol/min/mg]
18	Substrates and Products (Substrate)
2	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Temperature Stability [°C]
3	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.4.1.2 - homocysteine desulfhydrase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2,2'-dithiodiethylanol

Trichomonas vaginalis

-

-

34598

2,4-Dichlorophenol

Trichomonas vaginalis

-

-

34598

bithionol

Trichomonas vaginalis

-

-

34598

Dichlorophene

Trichomonas vaginalis

-

-

34598

dithiothreitol

Aspergillus fumigatus

-

10 mM, 86% loss of activity

722937

DL-Penicillamine

Trichomonas vaginalis

-

-

34599

DL-propargylglycine

Trichomonas vaginalis

-

-

34598, 34599

Hexachlorophene

Trichomonas vaginalis

-

-

34598

Hg2+

Aspergillus fumigatus

-

10 mM, 95% loss of activity

722937

hydroxylamine

2 entries

KCl

Aspergillus fumigatus

-

10 mM, 11% loss of activity

722937

L-Cycloserine

Trichomonas vaginalis

-

-

34599

SDS

Aspergillus fumigatus

-

10 mM, 78% loss of activity

722937

Tween 80

Aspergillus fumigatus

-

1 mM, about 40% loss of activity

722937

additional information

Aspergillus fumigatus

-

no inhibition by EDTA

722937

-

hydroxylamine

Aspergillus fumigatus

-

10 mM, 89% loss of activity

722937

hydroxylamine

Trichomonas vaginalis

-

-

34599