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4.4.1.16: selenocysteine lyase

This is an abbreviated version!
For detailed information about selenocysteine lyase, go to the full flat file.

Word Map on EC 4.4.1.16

Reaction

L-selenocysteine
+
reduced acceptor
=
selenide
 +
L-alanine
 +
acceptor

Synonyms

ABA3-NifS, cpSL, CsdB, L-selenocysteine selenide-lyase, More, SCL, Scly, Sec lyase, selenocysteine beta-lyase, selenocysteine lyase, selenocysteine reductase, SLC, SufS

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.16 selenocysteine lyase

General Information

General Information on EC 4.4.1.16 - selenocysteine lyase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice affecting hepatic glucose and lipid homeostasis. Mice lacking the enzyme and raised on an Se-adequate diet exhibit hyperinsulinemia, hyperleptinemia, glucose intolerance, and hepatic steatosis, with increased hepatic oxidative stress, but maintain selenoprotein levels and circulating Se status. Insulin challenge of enyme KO mice results in attenuated Akt phosphorylation but does not decrease phosphorylation levels of AMP kinase alpha. Upon dietary Se restriction, enzyme KO animals develop several characteristics of metabolic syndrome, such as obesity, fatty liver, and hypercholesterolemia, with aggravated hyperleptinemia, hyperinsulinemia, and glucose intolerance. Hepatic glutathione peroxidase 1 and selenoprotein S production and circulating selenoprotein P levels are significantly diminished. Enzyme disruption increases the levels of insulin-signaling inhibitor insulin signaling inhibitor protein phosphatase 1B
metabolism
-
the enzyme is involved in selenocysteine biosynthesis. The interaction between selenocysteine lyase and selenophosphate synthetase occurs with a stoichiometry of 1:1
physiological function
additional information