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4.4.1.14: 1-aminocyclopropane-1-carboxylate synthase

This is an abbreviated version!
For detailed information about 1-aminocyclopropane-1-carboxylate synthase, go to the full flat file.

Word Map on EC 4.4.1.14

Reaction

S-adenosyl-L-methionine
=
1-aminocyclopropane-1-carboxylate
+
methylthioadenosine

Synonyms

1-aminocyclopropane carboxylic acid synthase, 1-aminocyclopropane-1-carboxylate synthase, 1-aminocyclopropane-1-carboxylate synthase 4, 1-aminocyclopropane-1-carboxylate synthase 6, 1-aminocyclopropane-1-carboxylate synthetase, 1-aminocyclopropane-1-carboxylic acid synthase, 1-aminocyclopropanecarboxylate synthase, ACACS2 gene, ACC synthase, ACS, ACS-1, ACS1, ACS2, ACS3, ACS4, ACS5, ACS6, ACS7, ACS9, aminocyclopropane-1-carboxylate synthase, aminocyclopropane-2-carboxylic acid synthase, aminocyclopropanecarboxylate synthase, aminocyclopropanecarboxylic acid synthase, ASC, AtACS4 gene, Ca-ACS1, CyACS1, DC-ACS1, DC-ACS2, GhACS1, LE-ACS1A, LE-ACS2, LE-ACS3, LE-ACS4, LE-ACS6, LeACS2, MA-ACS4, MdACS1, MdACS3, MdACS5B, OsACS1, PgACS1, PgACS2, PgACS3a, PgACS3b, PgACS4, PmACS2, PmACS3, PmACS4, Pp-ACS1, S-adenosyl-L-methionine methylethioadenosine-lyase, S-adenosyl-L-methionine methylthioadenosine-lyase, S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming), synthase, 1-aminocyclopropanecarboxylate, type 2 1-aminocyclopropane-1-carboxylate synthase, type-2 ACC synthase

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.14 1-aminocyclopropane-1-carboxylate synthase

Inhibitors

Inhibitors on EC 4.4.1.14 - 1-aminocyclopropane-1-carboxylate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E,3E)-4-(2-aminoethoxy)-2-[([3-hydroxy-2-methyl-5[(phosphonooxy)methyl]pyridin-4-yl]methyl)imino] but-3-enoic acid
1-aminocyclopropane-1-carboxylate
-
-
1-methylcyclopropene
B2XCJ7, B2XCJ8; B2XCJ9; B2XCK0, B2XCK1, B2XCK2
completely inhibits the ethylene-associated transcription of isozyme ACS1 in the whole fruit; completely inhibits the ethylene-associated transcription of isozyme ACS4 in the whole fruit
2-(cyclopentylamino)-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one
inhibition of ethylene biosynthesis at the step of converting S-adenosylmethionine to 1-aminocyclopropane-1-carboxylic acid by ACC synthase
2-(cyclopentylamino)-7-(4-methylphenyl)-7,8-dihydroquinazolin-5(6H)-one
inhibition of ethylene biosynthesis at the step of converting S-adenosylmethionine to 1-aminocyclopropane-1-carboxylic acid by ACC synthase
2-amino-7-(4-methylphenyl)-7,8-dihydro-5(6H)-quinazolinone
2-aminooxyisobutyric acid
-
75% inhibition at 1.1 mM. The compound's action resembles aminooxyacetic acid. The inhibitor significantly increases the vase life of cut flowers by highly reducing the ethylene production through inhibition of the enzyme
2-[(3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl)-imino]-5-phosphonopent-3-enoic acid
7-(4-methoxyphenyl)-2-(phenylamino)-7,8-dihydroquinazolin-5(6H)-one
inhibition of ethylene biosynthesis at the step of converting S-adenosylmethionine to 1-aminocyclopropane-1-carboxylic acid by ACC synthase
aminoethoxyvinylglycine
aminooxyacetic acid
chlorpromazine
-
and analogs
EOL1
-
also named ETO1-LIKE 1, directs the degradation of type-2 ACS proteins (ACS4, ACS5 and ACS9) but not of type-1 or type-3 ACSs
-
ethylene
ACS6 is negatively regulated by endogenous and exogenous ethylene
homocysteine
-
slight
L-canaline
-
-
L-Vinylglycine
L-vinylglyine
-
-
methoxyethoxyvinylglycine
-
-
methoxyvinylglycine
-
slight
methylthioadenosine
-
weak
propyl 3,4,5-trihydroxybenzoate
-
-
putrescine
-
-
rhizobitoxine
-
-
S-(3-deazaadenosyl)homocysteine
-
-
S-adenosyl-L-homocysteine
-
-
S-adenosyl-L-methionine
S-adenosylhomocysteine
-
-
S-isobutyl-1-deazaadenosine
-
-
S-isobutyl-3-deazaadenosine
-
-
S-isobutyl-7-deazaadenosine
-
-
S-isobutyladenosine
-
-
S-methyl-L-methionine
-
covalent inactivation after elimination of dimethylsulfide
Semicarbazide
-
-
sinefungin
spermidine
-
-
Trifluoperazine
-
-