4.4.1.13: cysteine-S-conjugate beta-lyase

This is an abbreviated version!
For detailed information about cysteine-S-conjugate beta-lyase, go to the full flat file.

Reaction

Synonyms

AAR, beta-cystathionase, beta-lyase, C-DES, C-S lyase, CBL, CBL/ALR, CBS, CCBL2, Ctl1, Ctl2, cystathionine beta-lyase, cystathionine beta/gamma-lyase, cystathionine lyase, cysteine conjugate beta-lyase, cysteine conjugate. beta.-lyase, cysteine lyase, cysteine S-conjugate beta-lyase, cysteine-S-conjugate beta-lyase, cystine C-S lyase, cystine lyase, EC 4.4.1.6, EC 4.4.1.8, EcCBL, glutamine transaminase K, glutamine transaminase K/cysteine conjugate beta-lyase, GTK, Irc7p, KAT, KAT III, KYAT3, kynurenine aminotransferase, kynurenine-oxoglutarate transaminase 3, L-cystine C-S lyase, LACBS_00576, lyase, cystathionine beta-, lyase, cysteine conjugate.beta., MalY, MetC, More, Mp CBL, ORF5, osteotoxin, patB, PatB protein, Str3p, TmCBL, TTHA1620, wMelCBL

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.13 cysteine-S-conjugate beta-lyase

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Results	in table
8	Activating Compound
11220	AA Sequence
11	Application
2	CAS Registry Number
36	Cloned(Commentary)
71	Cofactor
6	Crystallization (Commentary)
99	Disease/ Diagnostics
4	Expression
44	General Information
11	General Stability
30	IC50 Value
148	Inhibitors
41	kcat/KM [mM/s]
11	Ki Value [mM]
137	KM Value [mM]
40	Localization
2	Metals/Ions
56	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
167	Organism
20	Pathway
32	PDB ID
43	pH Optimum
13	pH Range
5	pH Stability
2	pI Value
2	Posttranslational Modification
42	Protein Variants
59	Purification (Commentary)
11	Reaction
19	Reaction Type
161	Reference
1	Renatured (Commentary)
90	Source Tissue
37	Specific Activity [micromol/min/mg]
18	Storage Stability
421	Substrates and Products (Substrate)
47	Subunits
127	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
2	Temperature Range [°C]
20	Temperature Stability [°C]
41	Turnover Number [1/s]

pH Range

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pH Range on EC 4.4.1.13 - cysteine-S-conjugate beta-lyase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.5 - 6.8

Lacticaseibacillus casei

A6YH85

MalY: 55% of maximal activity at pH 5.5, optimal activity at pH 6.0, reduced activity at pH 6.8, no activity at pH 9.0

690554

5.5 - 8

Rattus norvegicus

-

-

34549

5.5 - 9

Lacticaseibacillus casei

A6YH85

MetC: 15% of maximal activity at pH 5.5, optimal activity at pH 9.0

690554

5.5 - 9.5

Fusobacterium varium

-

-

34553

7 - 10.5

Saccharomyces cerevisiae

E3VL26

using L-cystathionine as substrate, no significant activity is observed below pH 7.0 or above pH 10.5

713846

7 - 9.5

Pseudomonas cruciviae

-

-

34681

7.2 - 9

Escherichia coli

-

pH 7.2: 36% of maximal activity, pH 8.0-9.0: optimum

34690

7.4 - 8.5

Rattus norvegicus

-

-

34541

7.5 - 11.5

Latilactobacillus sakei

A0A223K4L6

activity range, profile overview

747857

7.5 - 9

Spinacia oleracea

-

pH 7.5: about 20% of maximal activity, pH 7.5-9.0: optimum

34699

7.5 - 9.5

Rattus norvegicus

-

50% of optimal activity at 7.5 and 9.5

34542

8 - 10

Rattus norvegicus

-

-

34548

8.4 - 9.9

Brassica oleracea

-

pH 8.4: about 55% of maximal activity, pH 9.9: about 30% of maximal activity

651551