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4.4.1.13: cysteine-S-conjugate beta-lyase

This is an abbreviated version!
For detailed information about cysteine-S-conjugate beta-lyase, go to the full flat file.

Word Map on EC 4.4.1.13

Reaction

2-aminoprop-2-enoate
=
2-iminopropanoate

Synonyms

AAR, beta-cystathionase, beta-lyase, C-DES, C-S lyase, CBL, CBL/ALR, CBS, CCBL2, Ctl1, Ctl2, cystathionine beta-lyase, cystathionine beta/gamma-lyase, cystathionine lyase, cysteine conjugate beta-lyase, cysteine conjugate. beta.-lyase, cysteine lyase, cysteine S-conjugate beta-lyase, cysteine-S-conjugate beta-lyase, cystine C-S lyase, cystine lyase, EC 4.4.1.6, EC 4.4.1.8, EcCBL, glutamine transaminase K, glutamine transaminase K/cysteine conjugate beta-lyase, GTK, Irc7p, KAT, KAT III, KYAT3, kynurenine aminotransferase, kynurenine-oxoglutarate transaminase 3, L-cystine C-S lyase, LACBS_00576, lyase, cystathionine beta-, lyase, cysteine conjugate.beta., MalY, MetC, More, Mp CBL, ORF5, osteotoxin, patB, PatB protein, Str3p, TmCBL, TTHA1620, wMelCBL

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.13 cysteine-S-conjugate beta-lyase

Reference

Reference on EC 4.4.1.13 - cysteine-S-conjugate beta-lyase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tateishi, M.; Shimizu, H.
Cysteine conjugate beta-lyase
Methods Enzymol.
77
253-256
1981
Cavia porcellus, Oryctolagus cuniculus, Mesocricetus auratus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Stevens, J.L.; Jacoby, W.B.
Cysteine conjugate beta-lyase
Methods Enzymol.
113
510-515
1985
Rattus norvegicus
Manually annotated by BRENDA team
Tomisawa, H.; Ichihara, S.; Fukazawa, H.; Ichimoto, N.; Tateishi, M.; Yamamoto, I.
Purification and characterization of human hepatic cysteine-conjugate beta-lyase
Biochem. J.
235
569-575
1986
Homo sapiens
Manually annotated by BRENDA team
Stevens, J.L.; Robbins, J.D.; Byrd, R.A.
A purified cysteine conjugate beta-lyase from rat kidney cytosol. Requirement for an alpha-keto acid or an amino acid oxidase for activity and identity with soluble glutamine transaminase K
J. Biol. Chem.
261
15529-15537
1986
Rattus norvegicus
Manually annotated by BRENDA team
Lash, L.H.; Elfarra, A.A.; Anders, M.W.
Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane
J. Biol. Chem.
261
5930-5935
1986
Rattus norvegicus
Manually annotated by BRENDA team
Stevens, J.L.
Isolation and characterization of a rat liver enzyme with both cysteine conjugate beta-lyase and kynureninase activity
J. Biol. Chem.
260
7945-7950
1985
Rattus norvegicus
Manually annotated by BRENDA team
Stevens, J.L.
Cysteine conjugate beta-lyase activities in rat kidney cortex: subcellular localization and relationship to the hepatic enzyme
Biochem. Biophys. Res. Commun.
129
499-504
1985
Rattus norvegicus
Manually annotated by BRENDA team
Dohn, D.R.; Anders, M.W.
Assay of cysteine conjugate beta-lyase activity with S-(2-benzothiazolyl)cysteine as the substrate
Anal. Biochem.
120
379-386
1982
Rattus norvegicus
Manually annotated by BRENDA team
Tateishi, M.; Suzuki, S.; Shimizu, H.
Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs
J. Biol. Chem.
253
8854-8859
1978
Rattus norvegicus
Manually annotated by BRENDA team
Stevens, J.; Hayden, P.; Taylor, G.
The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells
J. Biol. Chem.
261
3325-3332
1986
Sus scrofa
Manually annotated by BRENDA team
Stevens, J.L.; Ayoubi, N.; Robbins, J.D.
The role of mitochondrial matrix enzymes in the metabolism and toxicity of cysteine conjugates
J. Biol. Chem.
263
3395-3401
1988
Rattus norvegicus
Manually annotated by BRENDA team
Tomisawa, H.; Suzuki, S.; Ichihara, S.; Fukazawa, H.; Tateishi, M.
Purification and characterization of C-S lyase from Fusobacterium varium. A C-S cleavage enzyme of cysteine conjugates and some S-containing amino acids
J. Biol. Chem.
259
2588-2593
1984
Fusobacterium varium
Manually annotated by BRENDA team
Jakoby, W.B.; Stevens, J.
Cysteine conjugate beta-lyase and the thiomethyl shunt
Biochem. Soc. Trans.
12
33-35
1984
Rattus norvegicus
Manually annotated by BRENDA team
Kim, H.S.; Cha, S.H.; Abraham, D.G.; Cooper, A.J.L.; Endou, H.
Intranephron distribution of cysteine S-conjugate beta-lyase activity and its implication for hexachloro-1,3-butadiene-induced nephrotoxicity in rats
Arch. Toxicol.
71
131-141
1997
Rattus norvegicus
Manually annotated by BRENDA team
Yamauchi, A.; Stijntjes, G.J.; Commandeur, J.N.M.; Vermeulen, N.P.E
Purification of glutamine transaminase K/cysteine conjugate beta-lyase from rat renal cytosol based on hydrophobic interaction HPLC and gel permeation FPLC
Protein Expr. Purif.
4
552-562
1993
Rattus norvegicus
Manually annotated by BRENDA team
Banki, K.; Anders, M.W.
Inhibition of rat kidney mitochondrial DNA, RNA and protein synthesis by halogenated cysteine S-conjugates
Carcinogenesis
10
767-772
1989
Rattus norvegicus
Manually annotated by BRENDA team
Abraham, D.G.; Patel, P.P.; Cooper, A.J.L.
Isolation from rat kidney of a cytosolic high molecular weight cysteine-S-conjugate beta-lyase with activity toward leukotriene E4
J. Biol. Chem.
270
180-188
1995
Rattus norvegicus
Manually annotated by BRENDA team
Stevens, J.L.; Hatzinger, P.B.; Hayden, P.J.
Quantitation of multiple pathways for the metabolism of nephrotoxic cysteine conjugates using selective inhibitors of L-alpha-hydroxy acid oxidase (L-amino acid oxidase) and cysteine conjugate beta-lyase
Drug Metab. Dispos.
17
297-303
1989
Rattus norvegicus
Manually annotated by BRENDA team
Lash, L.H.; Nelson, R.M.; van Dyke, R.A.; Anders, M.W.
Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity
Drug Metab. Dispos.
18
50-54
1990
Homo sapiens
Manually annotated by BRENDA team
Alberati-Giani, D.; Malherbe, P.; Köhler, C.; Lang, G.; Kiefer, V.; Lahm, H.W.; Cesura, A.M.
Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase
J. Neurochem.
64
1448-1455
1995
Rattus norvegicus
Manually annotated by BRENDA team
MacFarlane, M.; Foster, J.R.; Gibson, G.G.; King, L.J.; Lock, E.A.
Cysteine conjugate beta-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity
Toxicol. Appl. Pharmacol.
98
185-197
1989
Rattus norvegicus
Manually annotated by BRENDA team
Kataoka, K.; Kinouchi, T.; Akimoto, S.; Ohnishi, Y.
Bioactivation of cysteine conjugates of 1-nitropyrene oxides by cysteine conjugate beta-lyase purified from Peptostreptococcus magnus
Appl. Environ. Microbiol.
61
3781-3787
1995
Finegoldia magna
Manually annotated by BRENDA team
Kitamura, N.; Shimomura, N.; Iseki, J.; Honma, M.; Chiba, S.; Tahara, S.; Mizutani, J.
Cysteine-S-conjugate beta-lyase activity and pyridoxal phosphate binding site of onion alliin lyase
Biosci. Biotechnol. Biochem.
61
1327-1330
1997
Mucor javanicus
Manually annotated by BRENDA team
Nishizuka, Y.
S-Alkyl-L-cysteine Lyase (Pseudomonas)
Methods Enzymol.
17B
470-474
1971
Pseudomonas cruciviae
-
Manually annotated by BRENDA team
Mazelis, M.; Creveling, R.K.
Purification and properties of S-alkyl-L-cysteine lyase from seedlings of Acacia farnesiana Willd.
Biochem. J.
147
485-491
1975
Vachellia farnesiana
Manually annotated by BRENDA team
Mazelis, M.
The cleavage of the ether linkage of O-methyl serine by the alkyl cysteine lyase of Acacia farnesiana
FEBS Lett.
54
193-195
1975
Vachellia farnesiana
Manually annotated by BRENDA team
Sweet, W.J.; Mazelis, M.
Homogeneous alkylcysteine lyase of Acacia farnesiana: Fresh seedlings vs. acetone powders
Phytochemistry
26
945-948
1987
Vachellia farnesiana
-
Manually annotated by BRENDA team
Nomura, J.; Nishizuta, Y.; Hayaishi, O.
S-Alkylcysteinease: Enzymatic cleavage of S-methyl-L-cysteine and its sulfoxide
J. Biol. Chem.
238
1441-1446
1963
Pseudomonas cruciviae
-
Manually annotated by BRENDA team
Kamitani, H.; Esaki, N.; Tanaka, H.; Soda, K.
Degradation of L-djenkolate catalyzed by S-alkylcysteine alpha,beta-lyase from Pseudomonas putida
J. Biochem.
109
645-649
1991
Pseudomonas putida
Manually annotated by BRENDA team
Kamitani, H.; Esaki, N.; Tanaka, H.; Soda, K.
Decomposition of L-selenodjenkolate catalyzed by S-alkylcysteine alpha, beta-lyase
Agric. Biol. Chem.
55
1659-1660
1991
Pseudomonas putida
-
Manually annotated by BRENDA team
Kamitani, H.; Esaki, N.; Tanaka, H.; Soda, K.
Thermostable S-alkylcysteine alpha, beta-lyase from a thermophile: purification and properties
Agric. Biol. Chem.
54
2069-2076
1990
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) 41A
Manually annotated by BRENDA team
Uren, J.R.
Cystathionine beta-lyase from Escherichia coli
Methods Enzymol.
143
483-486
1987
Escherichia coli
Manually annotated by BRENDA team
Giovanelli, J.
Cystathionine beta-lyase from spinach
Methods Enzymol.
143
443-449
1987
Spinacia oleracea
-
Manually annotated by BRENDA team
Guggenheim, S.
beta-Cystathionase (Salmonella)
Methods Enzymol.
17B
439-442
1971
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium me-A15
-
Manually annotated by BRENDA team
Alting, A.C.; Engels, W.J.M.; van Schalkwijk, S.; Exterkate, F.A.
Purification and characterization of cystathionine beta-lyase from Lactococcus lactis subsp. cremonis B78 and its possible role in flavor development in cheese
Appl. Environ. Microbiol.
61
4037-4042
1995
Lactococcus lactis
Manually annotated by BRENDA team
Dwivedi, C.M.; Ragin, R.C.; Uren, J.R.
Cloning, purification, and characterization of beta-cystathionase from Escherichia coli
Biochemistry
21
3064-3069
1982
Escherichia coli
Manually annotated by BRENDA team
Burnell, J.N.; Whatley, F.R.
Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of serine transacetylase, O-acetylserine sulphydrylase and beta-cystathionase
Biochim. Biophys. Acta
481
246-265
1977
Paracoccus denitrificans, Paracoccus denitrificans 8944
Manually annotated by BRENDA team
Giovanelli, J.; Owens, L.D.; Mudd, S.H.
beta-Cystathionase. In vivo inactivation by rhizobitoxine and role of the enzyme in methionine biosynthesis in corn seedlings
Plant Physiol.
51
492-503
1972
Salmonella enterica subsp. enterica serovar Typhimurium, Spinacia oleracea, Zea mays
Manually annotated by BRENDA team
Giovanelli, J.; Mudd, S.H.
Transsulfuration in higher plants. Partial purification and properties of beta-cystathionase of spinach
Biochim. Biophys. Acta
227
654-670
1971
Spinacia oleracea
Manually annotated by BRENDA team
Owens, L.D.; Guggenheim, S.; Hilton, J.L.
Rhizobium-synthesized phytototoxin: an inhibitor of beta-cystathionase in Salmonella typhimurium
Biochim. Biophys. Acta
158
219-225
1968
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Flavin, M.; Slaughter, C.
Cystathionine cleavage enzymes of Neurospora
J. Biol. Chem.
239
2212-2219
1964
Neurospora crassa
Manually annotated by BRENDA team
Laber, B.; Clausen, T.; Huber, R.; Messerschmidt, A.; Egner, U.; Muller-Fahrnow, A.; Pohlenz, H.D.
Cloning, purification, and crystallization of Escherichia coli cystathionine beta-lyase
FEBS Lett.
379
94-96
1996
Escherichia coli
Manually annotated by BRENDA team
Giovanelli, J.; Owens, L.D.; Mudd, H.
Mechanism of inhibition of spinach beta-cystathionase by rhizobitoxine
Biochim. Biophys. Acta
227
671-684
1971
Spinacia oleracea
Manually annotated by BRENDA team
McCluskey, T.J.; Scarf, A.R.; Anderson, J.W.
Enzyme catalysed alpha,beta-elimination of selenocystathionine and selenocystine and their sulphur isologues by plant extracts
Phytochemistry
25
2063-2068
1986
Astragalus sinicus, Pisum sativum, Spinacia oleracea
-
Manually annotated by BRENDA team
Droux, M.; Ravanel, S.; Douce, R.
Methionine biosynthesis in higher plants. II. Purification and characterization of cystathionine beta-lyase from spinach chloroplasts
Arch. Biochem. Biophys.
316
585-595
1995
Spinacia oleracea
Manually annotated by BRENDA team
Clausen, T.; Huber, R.; Messerschmidt, A.; Pohlenz, H.D.; Laber, B.
Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and x-ray study
Biochemistry
36
12633-12643
1997
Escherichia coli (P06721), Escherichia coli
Manually annotated by BRENDA team
Wallsgrove, R.M.; Lea, P.J.; Miflin, B.J.
Intracellular localization of aspartate kinase and the enzymes of threonine and methionine biosynthesis in green leaves
Plant Physiol.
71
780-784
1983
Hordeum vulgare, Pisum sativum
Manually annotated by BRENDA team
Morinaga, Y.; Tani, Y.; Yamada, H.
Biosynthesis of homocysteine in a facultative methylotroph, Pseudomonas FM518
Agric. Biol. Chem.
47
2855-2860
1983
Pseudomonas sp., Pseudomonas sp. FM518
-
Manually annotated by BRENDA team
Michaeli, S.; Ron, E.Z.
The metC gene in Escherichia coli K-12: isolation and studies of relatedness in Enterobacteriaceae
FEMS Microbiol. Lett.
22
31-35
1984
Escherichia coli
-
Manually annotated by BRENDA team
Burnell, J.N.
Sulfate assimilation in C4 plants. Intercellular and intracellular location of ATP sulfurylase, cysteine synthase, and cystathionine beta-lyase in maize leaves
Plant Physiol.
75
873-875
1984
Zea mays
Manually annotated by BRENDA team
Belfaiza, J.; Parsot, C.; Martel, A.; Bouthier de la Tour, C.; Margarita, D.; Cohen, G.N.; Saint-Girons, I.
Evolution in biosynthetic pathways: two enzymes catalyzing consecutive steps in methionine biosynthesis originate from a common ancestor and possess a similar regulatory region
Proc. Natl. Acad. Sci. USA
83
867-871
1986
Escherichia coli
Manually annotated by BRENDA team
Martel, A.; Bouthier de la Tour, C.; le Goffic, F.
Pyridoxal 5 phosphate binding site of Escherichia coli beta cystathionase and cystathionine gamma synthase comparison of their sequences
Biochem. Biophys. Res. Commun.
147
565-571
1987
Escherichia coli
Manually annotated by BRENDA team
Park, Y.M.; Stauffer, G.V.
Cloning and characterization of the metC gene from Salmonella typhimurium LT2
Gene
60
291-297
1987
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Sakata, T.; Hiroishi, S.; Kadota, H.
Occurrence of two types of cystathionine beta-cleavage enzyme in Bacillus subtilis
Agric. Biol. Chem.
36
333-335
1972
Bacillus subtilis
-
Manually annotated by BRENDA team
Ravanel, S.; Job, D.; Douce, R.
Purification and properties of cystathionine beta-lyase from Arabidopsis thaliana overexpressed in Escherichia coli
Biochem. J.
320
383-392
1996
Arabidopsis thaliana
Manually annotated by BRENDA team
Turner, W.L.; Pallett, K.E.; Lea, P.J.
Cystathionine beta-lyase from Echinochloa colonum tissue culture
Phytochemistry
47
189-196
1998
Echinochloa colona
-
Manually annotated by BRENDA team
Clausen, T.; Huber, R.; Laber, B.; Pohlenz, H.D.; Messerschmidt, A.
Crystal structure of the pyridoxal-5 -phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A
J. Mol. Biol.
262
202-224
1996
Escherichia coli
Manually annotated by BRENDA team
Gentry-Weeks, C.R.; Keith, J.M.; Thompson, J.
Toxicity of Bordetella avium beta-cystathionase toward MC3T3-E1 osteogenic cells
J. Biol. Chem.
268
7298-7314
1993
Bordetella avium
Manually annotated by BRENDA team
Gentry-Weeks, C.R.; Spokes, J.; Thompson, J.
beta-Cystathionase from Bordetella avium. Role(s) of lysine 214 and cysteine residues in activity and cytotoxicity
J. Biol. Chem.
270
7695-7702
1995
Bordetella avium
Manually annotated by BRENDA team
Clausen, T.; Laber, B.; Messerschmidt, A.
Mode of action of cystathionine beta-lyase
Biol. Chem.
378
321-326
1997
Escherichia coli
Manually annotated by BRENDA team
Staton, A.L.; Mazelis, M.
The C-S lyases of higher plants: homogeneous beta-cystathionase of spinach leaves
Arch. Biochem. Biophys.
290
46-50
1991
Spinacia oleracea
Manually annotated by BRENDA team
Tsai, M.D.; Weaver, J.; Floss, H.G.; Conn, E.E.; Creveling, R.K.; Mazelis, M.
Stereochemistry of the beta-cyanoalanine synthetase and S-alkylcysteine lyase reactions
Arch. Biochem. Biophys.
190
553-559
1978
Vachellia farnesiana
Manually annotated by BRENDA team
Cooper, A.J.; Bruschi, S.A.; Conway, M.; Hutson, S.M.
Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation
Biochem. Pharmacol.
65
181-192
2003
Homo sapiens
Manually annotated by BRENDA team
Commandeur, J.N.; Andreadou, I.; Rooseboom, M.; Out, M.; de Leur, L.J.; Groot, E.; Vermeulen, N.P.
Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K
J. Pharmacol. Exp. Ther.
294
753-761
2000
Rattus norvegicus
Manually annotated by BRENDA team
Fernandez, M.; van Doesburg, W.; Rutten, G.A.; Marugg, J.D.; Alting, A.C.; van Kranenburg, R.; Kuipers, O.P.
Molecular and functional analyses of the metC gene of Lactococcus lactis, encoding cystathionine beta-lyase
Appl. Environ. Microbiol.
66
42-48
2000
Lactococcus lactis (A2RM21), Lactococcus lactis
Manually annotated by BRENDA team
Gul Altuntas, T.; Kharasch, E.D.
Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism
Drug Metab. Dispos.
30
148-154
2002
Homo sapiens
Manually annotated by BRENDA team
Wakabayashi, H.; Wakabayashi, M.; Eisenreich, W.; Engel, K.H.
Stereoselectivity of the beta-lyase-catalyzed cleavage of S-cysteine conjugates of pulegone
Eur. Food Res. Technol.
215
287-292
2002
Eubacterium limosum
-
Manually annotated by BRENDA team
Adcock, H.J.; Brophy, P.M.; Teesdale-Spittle, P.H.; Buckberry, L.D.
Cysteine conjugate beta-lyase activity in three species of parasitic helminth
Int. J. Parasitol.
29
543-548
1999
Moniezia expansa, Heligmosomoides polygyrus, Necator americanus
Manually annotated by BRENDA team
Adcock, H.J.; Brophy, P.M.; Teesdale-Spittle, P.H.; Buckberry, L.D.
Purification and characterisation of a novel cysteine conjugate beta-lyase from the tapeworm Moniezia expansa
Int. J. Parasitol.
30
567-571
2000
Monieza expansa
Manually annotated by BRENDA team
Ramirez, E.C.; Whitaker, J.R.
Biochemical characterization of cystine lyase from broccoli (Brassica oleracea var. italica)
J. Agric. Food Chem.
47
2218-2225
1999
Brassica oleracea
Manually annotated by BRENDA team
Wakabayashi, H.; Wakabayashi, M.; Eisenreich, W.; Engel, K.H.
Stereochemical course of the generation of 3-mercaptohexanal and 3-mercaptohexanol by beta-lyase-catalyzed cleavage of cysteine conjugates
J. Agric. Food Chem.
52
110-116
2004
Eubacterium limosum, Escherichia coli
Manually annotated by BRENDA team
Jones, P.R.; Manabe, T.; Awazuhara, M.; Saito, K.
A new member of plant CS-lyases. A cystine lyase from Arabidopsis thaliana
J. Biol. Chem.
278
10291-10296
2003
Arabidopsis thaliana, Brassica oleracea (Q84UD0), Brassica oleracea
Manually annotated by BRENDA team
Kaiser, J.T.; Bruno, S.; Clausen, T.; Huber, R.; Schiaretti, F.; Mozzarelli, A.; Kessler, D.
Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state
J. Biol. Chem.
278
357-365
2003
Synechocystis sp.
Manually annotated by BRENDA team
Zhang, L.; Hanigan, M.H.
Role of cysteine S-conjugate beta-lyase in the metabolism of cisplatin
J. Pharmacol. Exp. Ther.
306
988-994
2003
Homo sapiens
Manually annotated by BRENDA team
Aubel, D.; Germond, J.E.; Gilbert, C.; Atlan, D.
Isolation of the patC gene encoding the cystathionine beta-lyase of Lactobacillus delbrueckii subsp. bulgaricus and molecular analysis of inter-strain variability in enzyme biosynthesis
Microbiology
148
2029-2036
2002
Lactobacillus delbrueckii
Manually annotated by BRENDA team
Chang, Z.; Vining, L.C.
Biosynthesis of sulfur-containing amino acids in Streptomyces venezuelae ISP5230: roles for cystathionine beta-synthase and transsulfuration
Microbiology
148
2135-2147
2002
Streptomyces venezuelae (Q9EYM7), Streptomyces venezuelae ISP5230 (Q9EYM7)
Manually annotated by BRENDA team
Maimann, S.; Wagner, C.; Kreft, O.; Zeh, M.; Willmitzer, L.; Hofgen, R.; Hesse, H.
Transgenic potato plants reveal the indispensable role of cystathionine beta-lyase in plant growth and development
Plant J.
23
747-758
2000
Solanum tuberosum (Q9MT31), Solanum tuberosum
Manually annotated by BRENDA team
Breitinger, U.; Clausen, T.; Ehlert, S.; Huber, R.; Laber, B.; Schmidt, F.; Pohl, E.; Messerschmidt, A.
The three-dimensional structure of cystathionine beta-lyase from Arabidopsis and its substrate specificity
Plant Physiol.
126
631-642
2001
Arabidopsis thaliana (P53780)
Manually annotated by BRENDA team
Clausen, T.; Kaiser, J.T.; Steegborn, C.; Huber, R.; Kessler, D.
Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis
Proc. Natl. Acad. Sci. USA
97
3856-3861
2000
Synechocystis sp.
Manually annotated by BRENDA team
Cooper, A.J.; Pinto, J.T.
Cysteine S-conjugate beta-lyases
Amino Acids
30
1-15
2006
Rattus norvegicus
Manually annotated by BRENDA team
Cooper, A.J.; Pinto, J.T.
Aminotransferase, L-amino acid oxidase and beta-lyase reactions involving L-cysteine S-conjugates found in allium extracts. Relevance to biological activity?
Biochem. Pharmacol.
69
209-220
2005
Rattus norvegicus
Manually annotated by BRENDA team
Bertoldi, M.; Cellini, B.; Laurents, D.V.; Borri Voltattorni, C.
Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli
Biochem. J.
389
885-898
2005
Escherichia coli
Manually annotated by BRENDA team
Arai, R.; Nishimoto, M.; Toyama, M.; Terada, T.; Kuramitsu, S.; Shirouzu, M.; Yokoyama, S.
Conserved protein TTHA1554 from Thermus thermophilus HB8 binds to glutamine synthetase and cystathionine beta-lyase
Biochim. Biophys. Acta
1750
40-47
2005
Thermus thermophilus HB8
Manually annotated by BRENDA team
Auger, S.; Gomez, M.P.; Danchin, A.; Martin-Verstraete, I.
The PatB protein of Bacillus subtilis is a C-S-lyase
Biochimie
87
231-238
2005
Bacillus subtilis
Manually annotated by BRENDA team
Ejim, L.J.; D'Costa, V.M.; Elowe, N.H.; Loredo-Osti, J.C.; Malo, D.; Wright, G.D.
Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium
Infect. Immun.
72
3310-3314
2004
Salmonella enterica
Manually annotated by BRENDA team
Lee, W.J.; Banavara, D.S.; Hughes, J.E.; Christiansen, J.K.; Steele, J.L.; Broadbent, J.R.; Rankin, S.A.
Role of cystathionine beta-lyase in catabolism of amino acids to sulfur volatiles by genetic variants of Lactobacillus helveticus CNRZ 32
Appl. Environ. Microbiol.
73
3034-3039
2007
Lactobacillus helveticus
Manually annotated by BRENDA team
Zhang, L.; Cooper, A.J.; Krasnikov, B.F.; Xu, H.; Bubber, P.; Pinto, J.T.; Gibson, G.E.; Hanigan, M.H.
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells
Biochemistry
45
8959-8971
2006
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Campanini, B.; Schiaretti, F.; Abbruzzetti, S.; Kessler, D.; Mozzarelli, A.
Sulfur mobilization in cyanobacteria: the catalytic mechanism of L-cystine C-S lyase (C-DES) from synechocystis
J. Biol. Chem.
281
38769-38780
2006
Synechocystis sp. PCC 6714
Manually annotated by BRENDA team
Ejim, L.J.; Blanchard, J.E.; Koteva, K.P.; Sumerfield, R.; Elowe, N.H.; Chechetto, J.D.; Brown, E.D.; Junop, M.S.; Wright, G.D.
Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function
J. Med. Chem.
50
755-764
2007
Salmonella enterica, Escherichia coli (P06721)
Manually annotated by BRENDA team
Swiegers, J.H.; Capone, D.L.; Pardon, K.H.; Elsey, G.M.; Sefton, M.A.; Francis, I.L.; Pretorius, I.S.
Engineering volatile thiol release in Saccharomyces cerevisiae for improved wine aroma
Yeast
24
561-574
2007
Escherichia coli
Manually annotated by BRENDA team
Cooper, A.J.; Pinto, J.T.; Krasnikov, B.F.; Niatsetskaya, Z.V.; Han, Q.; Li, J.; Vauzour, D.; Spencer, J.P.
Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase
Arch. Biochem. Biophys.
474
72-81
2008
Homo sapiens
Manually annotated by BRENDA team
Han, Q.; Gao, Y.G.; Robinson, H.; Li, J.
Structural insight into the mechanism of substrate specificity of Aedes kynurenine aminotransferase
Biochemistry
47
1622-1630
2008
Aedes aegypti
Manually annotated by BRENDA team
Irmler, S.; Raboud, S.; Beisert, B.; Rauhut, D.; Berthoud, H.
Cloning and characterization of two Lactobacillus casei genes encoding a cystathionine lyase
Appl. Environ. Microbiol.
74
99-106
2008
Lacticaseibacillus casei, Lacticaseibacillus casei (A6YH85)
Manually annotated by BRENDA team
Townsend, D.M.; Tew, K.D.; He, L.; King, J.B.; Hanigan, M.H.
Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity
Biomed. Pharmacother.
63
79-85
2009
Mus musculus
Manually annotated by BRENDA team
Troccaz, M.; Benattia, F.; Borchard, G.; Clark, A.J.
Properties of recombinant Staphylococcus haemolyticus cystathionine beta-lyase (metC) and its potential role in the generation of volatile thiols in axillary malodor
Chem. Biodivers.
5
2372-2385
2008
Staphylococcus haemolyticus
Manually annotated by BRENDA team
Thibon, C.; Marullo, P.; Claisse, O.; Cullin, C.; Dubourdieu, D.; Tominaga, T.
Nitrogen catabolic repression controls the release of volatile thiols by Saccharomyces cerevisiae during wine fermentation
FEMS Yeast Res.
8
1076-1086
2008
Saccharomyces cerevisiae (P43623), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Rankin, G.O.; Hong, S.K.; Anestis, D.K.; Ball, J.G.; Valentovic, M.A.
Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity
Toxicology
245
123-129
2008
Rattus norvegicus
Manually annotated by BRENDA team
Farsi, A.; Lodha, P.H.; Skanes, J.E.; Los, H.; Kalidindi, N.; Aitken, S.M.
Interconversion of a pair of active-site residues in Escherichia coli cystathionine gamma-synthase, E. coli cystathionine beta-lyase, and Saccharomyces cerevisiae cystathionine gamma-lyase and development of tools for the investigation of their mechanisms
Biochem. Cell Biol.
87
445-457
2009
Escherichia coli
Manually annotated by BRENDA team
Cooper, A.J.; Krasnikov, B.F.; Niatsetskaya, Z.V.; Pinto, J.T.; Callery, P.S.; Villar, M.T.; Artigues, A.; Bruschi, S.A.
Cysteine S-conjugate beta-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents
Amino Acids
41
7-27
2011
Rattus norvegicus
Manually annotated by BRENDA team
Barshteyn, N.; Elfarra, A.A.
Cysteine conjugate beta-lyase activity of rat erythrocytes and formation of beta-lyase-derived globin monoadducts and cross-links after in vitro exposure of erythrocytes to S-(1,2-dichlorovinyl)-L-cysteine
Chem. Res. Toxicol.
22
1351-1358
2009
Rattus norvegicus
Manually annotated by BRENDA team
Irmler, S.; Schäfer, H.; Beisert, B.; Rauhut, D.; Berthoud, H.
Identification and characterization of a strain-dependent cystathionine beta/gamma-lyase in Lactobacillus casei potentially involved in cysteine biosynthesis
FEMS Microbiol. Lett.
295
67-76
2009
Lacticaseibacillus casei (B3TNN8), Lacticaseibacillus casei (B3TNN9), Lacticaseibacillus casei
Manually annotated by BRENDA team
Schwiertz, A.; Deubel, S.; Birringer, M.
Bioactivation of selenocysteine derivatives by beta-lyases present in common gastrointestinal bacterial species
Int. J. Vitam. Nutr. Res.
78
169-174
2009
Parabacteroides distasonis, Phocaeicola vulgatus, Enterococcus faecalis, Enterococcus faecium, Enterococcus faecalis IFM, Enterococcus faecium IFM, Phocaeicola vulgatus IFM
Manually annotated by BRENDA team
Lodha, P.H.; Jaworski, A.F.; Aitken, S.M.
Characterization of site-directed mutants of residues R58, R59, D116, W340 and R372 in the active site of E. coli cystathionine beta-lyase
Protein Sci.
19
383-391
2010
Escherichia coli
Manually annotated by BRENDA team
Holt, S.; Cordente, A.G.; Williams, S.J.; Capone, D.L.; Jitjaroen, W.; Menz, I.R., Curtin, C.; Anderson, P.A.
Engineering Saccharomyces cerevisiae to release 3-mercaptohexan-1-ol during fermentation through overexpression of an S. cerevisiae gene, STR3, for improvement of wine aroma
Appl. Environ. Microbiol.
77
3626-3632
2011
Saccharomyces cerevisiae (E3VL26), Saccharomyces cerevisiae, Saccharomyces cerevisiae EC1118 (E3VL26)
Manually annotated by BRENDA team
Sengupta, N.; Alam, S.I.
In vivo studies of Clostridium perfringens in mouse gas gangrene model
Curr. Microbiol.
62
999-1008
2011
Clostridium perfringens
Manually annotated by BRENDA team
Katayama, R.; Nagata, S.; Iida, H.; Yamagishi, N.; Yamashita, T.; Furuhama, K.
Possible role of cysteine-S-conjugate beta-lyase in species differences in cisplatin nephrotoxicity
Food Chem. Toxicol.
49
2053-2059
2011
Canis lupus familiaris, Oryctolagus cuniculus, Felis sp., Mus musculus, Rattus norvegicus, Canis lupus familiaris Madnine Darbine, Mus musculus BALB/cCrSlc, Rattus norvegicus Fischer 344, Oryctolagus cuniculus New Zealand White
Manually annotated by BRENDA team
Jaworski, A.F.; Aitken, S.M.
Exploration of the six tryptophan residues of Escherichia coli cystathionine beta-lyase as probes of enzyme conformational change
Arch. Biochem. Biophys.
538
138-144
2013
Escherichia coli (P06721)
Manually annotated by BRENDA team
Manders, A.L.; Jaworski, A.F.; Ahmed, M.; Aitken, S.M.
Exploration of structure-function relationships in Escherichia coli cystathionine gamma-synthase and cystathionine beta-lyase via chimeric constructs and site-specific substitutions
Biochim. Biophys. Acta
1834
1044-1053
2013
Escherichia coli (P06721)
Manually annotated by BRENDA team
Reveal, B.S.; Paietta, J.V.
Sulfur-regulated control of the met-2+ gene of Neurospora crassa encoding cystathionine beta-lyase
BMC Res. Notes
6
259
2013
Neurospora crassa (Q1K8G0)
Manually annotated by BRENDA team
Pinto, J.T.; Krasnikov, B.F.; Alcutt, S.; Jones, M.E.; Dorai, T.; Villar, M.T.; Artigues, A.; Li, J.; Cooper, A.J.
Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate beta-lyase activity and can transaminate L-selenomethionine
J. Biol. Chem.
289
30950-30961
2014
Homo sapiens (Q6YP21), Homo sapiens
Manually annotated by BRENDA team
Munt, O.; Prüfer, D.; Schulze Gronover, C.
A novel C-S lyase from the latex-producing plant Taraxacum brevicorniculatum displays alanine aminotransferase and l-cystine lyase activity
J. Plant Physiol.
170
33-40
2013
Taraxacum brevicorniculatum
Manually annotated by BRENDA team
Yang, C.; Zhang, L.; Han, Q.; Liao, C.; Lan, J.; Ding, H.; Zhou, H.; Diao, X.; Li, J.
Kynurenine aminotransferase 3/glutamine transaminase L/cysteine conjugate beta-lyase 2 is a major glutamine transaminase in the mouse kidney
Biochem. Biophys. Rep.
8
234-241
2016
Mus musculus (Q71RI9), Mus musculus
Manually annotated by BRENDA team
Kato, S.; Oikawa, T.
A novel bifunctional amino acid racemase with multiple substrate specificity, malY from Lactobacillus sakei LT-13 Genome-based identification and enzymological characterization
Front. Microbiol.
9
403
2018
Latilactobacillus sakei (A0A223K4L6), Latilactobacillus sakei LT-13 (A0A223K4L6)
Manually annotated by BRENDA team
Oogai, S.; Fukuta, M.; Watanabe, K.; Inafuku, M.; Oku, H.
Molecular characterization of mimosinase and cystathionine beta-lyase in the Mimosoideae subfamily member Mimosa pudica
J. Plant Res.
132
667-680
2019
Mimosa pudica (A0A0M3VI47), Mimosa pudica
Manually annotated by BRENDA team
Ferla, M.P.; Brewster, J.L.; Hall, K.R.; Evans, G.B.; Patrick, W.M.
Primordial-like enzymes from bacteria with reduced genomes
Mol. Microbiol.
105
508-524
2017
Escherichia coli (P06721), Candidatus Pelagibacter ubique (Q4FME3), Wolbachia pipientis (Q73GL9), Thermotoga maritima (Q9X0Z7), Wolbachia pipientis wMel (Q73GL9), Candidatus Pelagibacter ubique HTCC1062 (Q4FME3), Thermotoga maritima DSM 3109 (Q9X0Z7), Thermotoga maritima ATCC 43589 (Q9X0Z7), Thermotoga maritima JCM 10099 (Q9X0Z7)
Manually annotated by BRENDA team