4.4.1.13: cysteine-S-conjugate beta-lyase
This is an abbreviated version!
For detailed information about cysteine-S-conjugate beta-lyase, go to the full flat file.
Word Map on EC 4.4.1.13
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4.4.1.13
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nephrotoxic
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kynurenic
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s-conjugates
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aminooxyacetic
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pyridoxal
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s-1,2-dichlorovinyl-l-cysteine
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mercapturic
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halogenated
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transamination
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beta-elimination
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aminotransferases
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kynureninase
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l-kynurenine
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alkene
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haloalkenes
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sevoflurane
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3-hydroxykynurenine
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gamma-lyase
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plp-dependent
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acivicin
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trichloroethylene
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gamma-synthase
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probenecid
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l-cystathionine
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transsulfuration
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hexachlorobutadiene
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xanthurenic
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nephrocarcinogenicity
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5'-phosphate-dependent
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methylselenol
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methanethiol
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b6-dependent
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se-methylselenocysteine
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sulfhydrylase
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o-acetylserine
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thioacylating
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organ-selective
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alpha-aminoadipate
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3-monooxygenase
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3-hydroxyanthranilic
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beta-replacement
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food industry
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nutrition
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agriculture
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medicine
- 4.4.1.13
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nephrotoxic
-
kynurenic
-
s-conjugates
-
aminooxyacetic
- pyridoxal
- s-1,2-dichlorovinyl-l-cysteine
-
mercapturic
-
halogenated
-
transamination
-
beta-elimination
- aminotransferases
- kynureninase
- l-kynurenine
- alkene
-
haloalkenes
- sevoflurane
- 3-hydroxykynurenine
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gamma-lyase
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plp-dependent
- acivicin
- trichloroethylene
-
gamma-synthase
- probenecid
- l-cystathionine
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transsulfuration
-
hexachlorobutadiene
-
xanthurenic
-
nephrocarcinogenicity
-
5'-phosphate-dependent
- methylselenol
- methanethiol
-
b6-dependent
- se-methylselenocysteine
-
sulfhydrylase
- o-acetylserine
-
thioacylating
-
organ-selective
- alpha-aminoadipate
-
3-monooxygenase
-
3-hydroxyanthranilic
-
beta-replacement
- food industry
- nutrition
- agriculture
- medicine
Reaction
Synonyms
AAR, beta-cystathionase, beta-lyase, C-DES, C-S lyase, CBL, CBL/ALR, CBS, CCBL2, Ctl1, Ctl2, cystathionine beta-lyase, cystathionine beta/gamma-lyase, cystathionine lyase, cysteine conjugate beta-lyase, cysteine conjugate. beta.-lyase, cysteine lyase, cysteine S-conjugate beta-lyase, cysteine-S-conjugate beta-lyase, cystine C-S lyase, cystine lyase, EC 4.4.1.6, EC 4.4.1.8, EcCBL, glutamine transaminase K, glutamine transaminase K/cysteine conjugate beta-lyase, GTK, Irc7p, KAT, KAT III, KYAT3, kynurenine aminotransferase, kynurenine-oxoglutarate transaminase 3, L-cystine C-S lyase, LACBS_00576, lyase, cystathionine beta-, lyase, cysteine conjugate.beta., MalY, MetC, More, Mp CBL, ORF5, osteotoxin, patB, PatB protein, Str3p, TmCBL, TTHA1620, wMelCBL
ECTree
4.4.1.13 cysteine-S-conjugate beta-lyaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.4.1.13 - cysteine-S-conjugate beta-lyase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-methionine + H2O
methanethiol + NH3 + 2-oxobutanoate
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?
cystathionine + H2O
?
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enzyme is involved in methionine biosynthesis
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-
?
cystathionine + H2O
?
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the second enzyme unique to methionine biosynthesis
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-
?
cystathionine + H2O
?
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enzyme is involved in methionine biosynthesis
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-
?
cystathionine + H2O
?
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enzyme is involved in methionine biosynthesis
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-
?
cystathionine + H2O
L-homocysteine + pyruvate + NH3
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-
-
?
cystathionine + H2O
L-homocysteine + pyruvate + NH3
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-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
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-
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
100% activity
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-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
100% activity
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-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
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penultimate step in microbial and plant methionine biosynthesis
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-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
overall reaction
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-
?
additional information
?
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the enzyme catalyzes the penultimate step in de novo biosynthesis of Met in microbes and plants
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?
additional information
?
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the enzyme is responsible for off-aroma deterioration in fresh unblanched broccoli
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?
additional information
?
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intestinal microflora: formation of methylthio-containing metabolites
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-
?
additional information
?
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cisplatin is bioactivated by the enzyme, renal toxicity of cisplatin results from enzyme activity, in contrast, carboplatin is not bioactivated
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?
additional information
?
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the enzyme is implicated in the degradation of not only cystathionine but also cysteine and methionine
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-
?
additional information
?
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the enzyme is implicated in the degradation of not only cystathionine but also cysteine and methionine
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-
?
additional information
?
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with methionine as substrate the enzyme produces volatile sulfur compounds which are important for flavor formation in Gouda cheese
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?
additional information
?
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with methionine as substrate the enzyme produces volatile sulfur compounds which are important for flavor formation in Gouda cheese
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?
additional information
?
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Ls-MalY is a bifunctional amino acid racemase with multiple substrate specificity, both the amino acid racemase and beta-lyase reactions of Ls-MalY are catalyzed at the same active site
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-
?
additional information
?
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cysteine S-conjugate beta-lyases catalyze beta-elimination reactions with cysteine S-conjugates that possess a good leaving group in the beta-position. The end products are aminoacrylate and a sulfur-containing fragment. The aminoacrylate tautomerizes and hydrolyzes to pyruvate and ammonia.
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-
?
additional information
?
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Irc7p, a putative cystathionine beta-lyase, is one of the main proteins catalyzing the 4-methyl-4-sulfanylpentan-2-one and 3-sulfanylhexan-1-ol, as aromatic compounds, release from inodorous nonvolatile cysteinylated precursors under enological conditions. The two other beta-lyases Ure2p and Gln3p mainly control the bioconversion of volatile thiols by the transcriptional regulation of the IRC7 gene through the general mechanism of nitrogen catabolic repression
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-
?
additional information
?
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Irc7p, a putative cystathionine beta-lyase, is one of the main proteins catalyzing the 4-methyl-4-sulfanylpentan-2-one and 3-sulfanylhexan-1-ol, as aromatic compounds, release from inodorous nonvolatile cysteinylated precursors under enological conditions. The two other beta-lyases Ure2p and Gln3p mainly control the bioconversion of volatile thiols by the transcriptional regulation of the IRC7 gene through the general mechanism of nitrogen catabolic repression
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?
additional information
?
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the enzyme catalyzes the penultimate step in methionine biosynthesis. The enzyme is important for bacterial virulence
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?
additional information
?
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the enzyme plays a central role in methionine biosynthesis
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?
additional information
?
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the enzyme plays a central role in methionine biosynthesis
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?
additional information
?
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the enzyme is involved in generation of sulfur-containing amino acids in streptomycete
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?
additional information
?
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the enzyme is involved in generation of sulfur-containing amino acids in streptomycete
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?
additional information
?
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the enzyme is a physiologically bifunctional alanine/glutamate racemase (EC 5.1.1.1/EC 5.1.1.3), it is not highly active, but it is clearly sufficient. The metC encoded L-alanine/L-glutamate racemase is a multifunctional CBL/ALR. CBL activity is no longer required in these bacteria
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additional information
?
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the enzyme is a physiologically bifunctional alanine/glutamate racemase (EC 5.1.1.1/EC 5.1.1.3), it is not highly active, but it is clearly sufficient. The metC encoded L-alanine/L-glutamate racemase is a multifunctional CBL/ALR. CBL activity is no longer required in these bacteria
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additional information
?
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the enzyme is a physiologically bifunctional alanine/glutamate racemase (EC 5.1.1.1/EC 5.1.1.3), it is not highly active, but it is clearly sufficient. The metC encoded L-alanine/L-glutamate racemase is a multifunctional CBL/ALR. CBL activity is no longer required in these bacteria
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