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4.4.1.13: cysteine-S-conjugate beta-lyase

This is an abbreviated version!
For detailed information about cysteine-S-conjugate beta-lyase, go to the full flat file.

Word Map on EC 4.4.1.13

Reaction

2-aminoprop-2-enoate
=
2-iminopropanoate

Synonyms

AAR, beta-cystathionase, beta-lyase, C-DES, C-S lyase, CBL, CBL/ALR, CBS, CCBL2, Ctl1, Ctl2, cystathionine beta-lyase, cystathionine beta/gamma-lyase, cystathionine lyase, cysteine conjugate beta-lyase, cysteine conjugate. beta.-lyase, cysteine lyase, cysteine S-conjugate beta-lyase, cysteine-S-conjugate beta-lyase, cystine C-S lyase, cystine lyase, EC 4.4.1.6, EC 4.4.1.8, EcCBL, glutamine transaminase K, glutamine transaminase K/cysteine conjugate beta-lyase, GTK, Irc7p, KAT, KAT III, KYAT3, kynurenine aminotransferase, kynurenine-oxoglutarate transaminase 3, L-cystine C-S lyase, LACBS_00576, lyase, cystathionine beta-, lyase, cysteine conjugate.beta., MalY, MetC, More, Mp CBL, ORF5, osteotoxin, patB, PatB protein, Str3p, TmCBL, TTHA1620, wMelCBL

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.13 cysteine-S-conjugate beta-lyase

Inhibitors

Inhibitors on EC 4.4.1.13 - cysteine-S-conjugate beta-lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(4-chlorophenyl)-3-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]urea
reversible inhibition
1-[3-(3,4-dichlorophenyl)isoxazol-5-yl]-2-[(4-thiophen-2-ylpyrimidin-2-yl)sulfanyl]ethanone
reversible inhibition
2,3,5-trifluoro-N-(2-hydrazino-2-oxoethyl)-4-methoxybenzamide
only poor inhibitor
2-bromobenzyl (9Z)-9-(hydroxyimino)-2,7-dinitro-9H-fluorene-4-carboxylate
hydrolysis of the oxime to generate hydroxylamine in situ that interacted with the PLP cofactor
3,3,3,-trifluoroalanine
3,3,3-trifluoro-N-(2-methylphenyl)-2-(trifluoromethyl)propanamide
reversible inhibition
3,4-dichlorobenzenesulfonohydrazide
known to interact with the cofactor of PLP enzymes
3,5-diamino-N-(2-hydrazino-2-oxoethyl)benzamide
-
3-amino-N-(2-hydrazino-2-oxoethyl)naphthalene-2-carboxamide
only poor inhibitor
3-hydroxykynurenine
-
cysteine conjugate beta-lyase activity
3-methyl-2-benzothiazolinone hydrazoone
-
-
4-chloro-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]benzamide
reversible inhibition
4-methylbenzenesulfonohydrazide
known to interact with the cofactor of PLP enzymes
5,5'-dithiobis(2-nitrobenzoic acid)
5-aminonaphthalene-1-sulfonohydrazide
known to interact with the cofactor of PLP enzymes
5-chlorothiophene-2-sulfonohydrazide
known to interact with the cofactor of PLP enzymes
5-pyridin-2-ylthiophene-2-sulfonohydrazide
known to interact with the cofactor of PLP enzymes
aminoethoxyvinylglycine
aminooxyacetic acid
aminooxyacetic acid hemihydrochloride
ammonium sulfate
-
66% inhibition at 4 mM
aromatic disulfide
-
-
-
Beta-cyanoalanine
carboxymethoxylamine
-
irreversible
diphenyl 9-(dicyanomethylidene)-4,5-dinitro-9H-fluorene-2,7-disulfonate
reversible inhibition
DL-cycloserine
-
irreversible
DL-homocysteine
-
12.5 mM, 70% inhibition, competitive inhibitor
DL-Penicillamine
-
-
DL-propargylglycine
DTT
-
10 mM, 19% inhibition
glutathione
-
strong
glycine
-
73% inhibition at 4 mM
HgCl2
-
57% inhibition at 1 mM
homocysteine
-
strong
hydoxylamine
-
complete inhibition at 1 mM
hydroxylamine
iodoacetamide
iodoacetate
kynurenine
-
cysteine conjugate beta-lyase activity
L-alpha-(2-aminoethoxyvinyl)glycine
L-aminoethoxyvinylglycine
time-dependent slow-binding, one-step mechanism
L-canaline
-
1 mM, 67% inhibition, 10 mM complete inhibition
L-cystathionine
-
substrate inhibition at concentrations above 6 mM
L-cysteine
-
12 mM, 65% inhibition after 5 min, 1 mM, 29% inhibition after 10 min, linear noncompetitive inhibitor
L-Met
-
competitive
L-methionine
-
40% inhibition at 6 mM
L-serine
-
86% inhibition at 4 mM
N-(2-hydrazino-2-oxoethyl)-2,6-dimethoxybenzamide
-
N-(2-hydrazino-2-oxoethyl)-2-(trifluoromethyl)benzamide
-
N-(2-hydrazino-2-oxoethyl)-2-naphthalen-1-ylacetamide
-
N-(2-hydrazino-2-oxoethyl)-2-nitrobenzamide
known to interact with the cofactor of PLP enzymes
N-(2-hydrazino-2-oxoethyl)-3,5-dinitrobenzamide
-
N-(2-hydrazino-2-oxoethyl)-3-(trifluoromethyl)benzamide
-
N-(2-hydrazino-2-oxoethyl)-4-(trifluoromethyl)benzamide
-
N-(2-hydrazino-2-oxoethyl)-4-nitrobenzamide
-
N-acetyl-L-cysteine
-
-
N-hydrazinocarbonylmethyl-2-nitrobenzamide
-
-
N-hydrazinocarbonylmethyl-2-trifluoromethylbenzamide
-
-
N-[4-(hydrazinosulfonyl)benzyl]acetamide
known to interact with the cofactor of PLP enzymes
NaF
-
10 mM, weak
O-acetylserine
-
strong
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
1 mM, 92% inhibition
phenylhydrazine
pyridoxal
-
12.5 mM, in presence of 12 mM L-cystine 12% inhibition, in presence of 1 mM L-cystine 37% inhibition
pyruvate
-
12.5 mM, 25% inhibition
rhizobitoxine
S-adenosylmethionine
-
weak
S-methyl-L-cysteine
-
substrate inhibition, when concentration exceeds 10 mM
Semicarbazide
-
-
Sodium cyanide
-
12.5 mM, 95% inhibition
additional information
-