4.4.1.11: methionine gamma-lyase
This is an abbreviated version!
For detailed information about methionine gamma-lyase, go to the full flat file.
Word Map on EC 4.4.1.11
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4.4.1.11
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lipase
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monoacylglycerol
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endocannabinoids
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cannabinoids
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lectin
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putida
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c-type
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2-arachidonoylglycerol
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pyridoxal
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medicine
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monoglyceride
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orthotopic
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galactose-type
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galnac
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selenomethionine
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anandamide
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freundii
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2-arachidonoyl
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citrobacter
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alpha-ketobutyrate
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methylselenol
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meibomian
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methionine-dependent
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mercaptan
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beta-lyase
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5'-phosphate-dependent
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dc-sign
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s-substituted
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synthesis
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nutrition
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environmental protection
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analysis
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drug development
- 4.4.1.11
- lipase
- monoacylglycerol
-
endocannabinoids
- cannabinoids
- lectin
- putida
-
c-type
- 2-arachidonoylglycerol
- pyridoxal
- medicine
- monoglyceride
-
orthotopic
-
galactose-type
- galnac
- selenomethionine
- anandamide
- freundii
-
2-arachidonoyl
-
citrobacter
- alpha-ketobutyrate
- methylselenol
-
meibomian
-
methionine-dependent
- mercaptan
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beta-lyase
-
5'-phosphate-dependent
-
dc-sign
-
s-substituted
- synthesis
- nutrition
- environmental protection
- analysis
- drug development
Reaction
Synonyms
CalE6, EhMGL1, EhMGL2, fer1MgL2, Fn1419, L-methionase, L-methioninase, L-methionine gamma-lyase, L-methionine gamma-lyase 1, L-methionine-alpha-deamino-gamma-mercaptomethane lyase, L-methionine-alpha-deamino-gamma-mercaptomethane-lyase, L-methionine-gamma-lyase, lyase, methionine, MdeA, MegL, METase, methioninase, methionine alpha,gamma-lyase, methionine dethiomethylase, methionine gamma-lyase, methionine lyase, methionine-gamma-lyase, MGL, MGL1, MGL2, rMETase, sav7062, TvMGL1, TvMGL2, YtjE
ECTree
4.4.1.11 methionine gamma-lyaseAdvanced search results
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results (General Information
General Information on EC 4.4.1.11 - methionine gamma-lyase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
the enzyme belongs to the subclass of cystathionine beta-lyase with type I folding of the polypeptide chain of pyridoxal 5'-phosphate-dependent enzymes
malfunction
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in planta silencing of StMGL1 results in an increased methionine to isoleucine ratio in the free amino acid profile of potato tubers and, in some transgenic lines, elevated accumulation of free methionine. In both wild-type and transgenic tubers, the ratio of methionine to isoleucine is negatively correlated with the level of StMGL1 transcript
metabolism
physiological function
additional information
metabolism
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the enzyme is responsible for the alpha,beta,gamma-elimination and gamma,beta-replacement in analogues of L-methionione such as L-homocysteine, through degradation to keto acids, ammonia, and H2S in anaerobic bacteria and parasitic protozoa
metabolism
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the enzyme is responsible for the alpha,beta,gamma-elimination and gamma,beta-replacement in analogues of L-methionione such as L-homocysteine, through degradation to keto acids, ammonia, and H2S in anaerobic bacteria and parasitic protozoa
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physiological function
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involvled in pathogenicity of periodontal bacterium
physiological function
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isoleucine biosynthesis, sulfur storage, involved in the alternative reverse-transsulfuration pathway, important roe in the resumption process
physiological function
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under drought conditions and in reproductive tissue enzyme might play significant role as an alternate route to fulfill increased demand for isoleucine
physiological function
the amount of H2S produced by Fn1419 is estimated to be 1.9% of the total H2S produced from L-cysteine in Fusobacterium nucleatum ATCC 25586
physiological function
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the catabolic enzyme methionine gamma-lyase limits methionine accumulation in potato tubers. In both wild-type and transgenic tubers, the ratio of methionine to isoleucine is negatively correlated with the level of StMGL1 transcript
physiological function
the pyridoxal5'-phosphate-dependent enzyme catalyzes the gamma-elimination and gamma-replacement of L-methionine and its derivatives and the reactions of beta-elimination and beta-replacement of L-cysteine and S-substituted L-cysteines. The enzyme also catalyzes the reactions of gamma-elimination and gamma-replacement of the phosphinic analogue of methionine, Met-PH. Met-PH has a high antibacterial activity, is an effective fungi cide under field conditions, and inhibits the growth of tumor cells due to transformation into a metabolically stable phosphonic analog of S-adenosylmethionine
physiological function
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Lack of methionine gamma-lyase in Porphyromonas gingivalis affects oral microbial ecology in vitro, giving rise to a markedly different biofilm composition, with a more pro-inflammatory cytokine response from the keratinocytes
physiological function
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silencing Solanum tuberosum methionine gamma-lyase increases tuber methionine levels. Solanum tuberosum cv. Desiree plants with overexpression of Arabidopsis thaliana cystathionine gamma-synthase and endogenous methionine gamma-lyase silenced by RNA interference are morphologically normal and accumulate higher free methionine levels than either single-transgenic line
physiological function
Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847
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the amount of H2S produced by Fn1419 is estimated to be 1.9% of the total H2S produced from L-cysteine in Fusobacterium nucleatum ATCC 25586
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additional information
catalytic residues: Lys210 is the base, and Tyr113 acts as a general acid, active site structure, overview
additional information
general acid catalytic residue is conserved Tyr114, conserved residue Lys240 is important for substrate recognition and structural stability, conserved residue Asp241 is also important in the elimination reaction, structure-function analysis, overview
