4.3.99.3: 7-carboxy-7-deazaguanine synthase
This is an abbreviated version!
For detailed information about 7-carboxy-7-deazaguanine synthase, go to the full flat file.
Word Map on EC 4.3.99.3
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4.3.99.3
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s-adenosyl-l-methionine
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radical-mediated
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adomet
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5\'-deoxyadenosyl
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7-deazapurine
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flavodoxin
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burkholderia
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dithionite
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sam-dependent
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pyrrolopyrimidine
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multivorans
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cluster-binding
- 4.3.99.3
- s-adenosyl-l-methionine
-
radical-mediated
- adomet
-
5\'-deoxyadenosyl
-
7-deazapurine
- flavodoxin
-
burkholderia
- dithionite
-
sam-dependent
-
pyrrolopyrimidine
- multivorans
-
cluster-binding
Reaction
Synonyms
7-carboxy-7-carbaguanine synthase, BsQueE, CDG synthase, queE, ToyC
ECTree
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Systematic Name
Systematic Name on EC 4.3.99.3 - 7-carboxy-7-deazaguanine synthase
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6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase
Requires Mg2+. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine.