4.3.99.3: 7-carboxy-7-deazaguanine synthase
This is an abbreviated version!
For detailed information about 7-carboxy-7-deazaguanine synthase, go to the full flat file.
Word Map on EC 4.3.99.3
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4.3.99.3
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s-adenosyl-l-methionine
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radical-mediated
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adomet
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5\'-deoxyadenosyl
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7-deazapurine
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flavodoxin
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burkholderia
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dithionite
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sam-dependent
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pyrrolopyrimidine
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multivorans
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cluster-binding
- 4.3.99.3
- s-adenosyl-l-methionine
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radical-mediated
- adomet
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5\'-deoxyadenosyl
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7-deazapurine
- flavodoxin
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burkholderia
- dithionite
-
sam-dependent
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pyrrolopyrimidine
- multivorans
-
cluster-binding
Reaction
Synonyms
7-carboxy-7-carbaguanine synthase, BsQueE, CDG synthase, queE, ToyC
ECTree
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General Information
General Information on EC 4.3.99.3 - 7-carboxy-7-deazaguanine synthase
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evolution
metabolism
additional information
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QueE is a member of the radical SAM organic radical generating enzyme superfamily. Members of the radical SAM superfamily contain a CX3CX2C-motif for binding a [4Fe-4S] cluster, which when reductively activated, cleaves SAM to 5'-deoxyadenosyl radical, which in turn initiates radical mediated transformations of the substrate
evolution
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QueE is a member of the radical S-adenosyl-L-methionine superfamily, all of which use a bound [4Fe-4S]+ cluster to catalyze the reductive cleavage of S-adenosyl-L-methionine cofactor to generate methionine and a 5'-deoxyadenosyl radical, which initiates enzymatic transformations requiring H-atom abstraction
evolution
QueE is a member of the radical S-adenosyl-L-methionine superfamily, it varies from the other members in that it contains a hypermodified (beta6/alpha3) protein core and an expanded cluster-binding motif CX14CX2C, structure comparisons, overview
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QueE is involved in the queuosine biosynthetic pathway of Bacillus subtilis
metabolism
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the enzyme catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin to 7-carboxy-7-carbaguanine in the third step of the biosynthetic pathway to all 7-deazapurines. 7-Carboxy-7-carbaguanine is the first 7-deazapurine in the biosynthetic pathway and likely the precursor to all naturally occurring 7-deazapurine containing molecules
metabolism
the enzyme catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin to 7-carboxy-7-carbaguanine in the third step of the biosynthetic pathway to all 7-deazapurines. 7-Carboxy-7-carbaguanine is the first 7-deazapurine in the biosynthetic pathway and likely the precursor to all naturally occurring 7-deazapurine containing molecules
metabolism
the enzyme catalyzes a key step in the biosynthesis of 7-deazapurine containing natural products
metabolism
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the enzyme catalyzes a key step in the biosynthesis of 7-deazapurine containing natural products
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additional information
substrate binding generates a metal-binding site
additional information
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substrate binding generates a metal-binding site