4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase

This is an abbreviated version!
For detailed information about 4-hydroxy-tetrahydrodipicolinate synthase, go to the full flat file.

Reaction

Synonyms

Aq_1143, AT2G45440, BA3935 gene product, cDHDPS, CjDHDPS, DapA, DapA2, DHDPA synthase, DHDPS, DHDPS2, dihydro-dipicolinic acid synthase, dihydrodipicolinate synthase, dihydrodipicolinic acid synthase, dihydrodipocolinate synthase, dihydropicolinate synthetase, EC 4.2.1.52, FaDHDPS, HTPA synthase, More, MosA, MosA protein, MRSA-DHDPS, PA1010, pyruvate-aspartic semialdehyde condensing enzyme, Rv2753c, synthase, dihydrodipicolinate, VEG81, Vegetative protein 81

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.3 Amine-lyases

                4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase

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Results	in table
10	Activating Compound
50367	AA Sequence
34	Application
1	CAS Registry Number
67	Cloned(Commentary)
3	Cofactor
52	Crystallization (Commentary)
1	Expression
51	General Information
6	General Stability
13	IC50 Value
219	Inhibitors
28	kcat/KM [mM/s]
53	Ki Value [mM]
140	KM Value [mM]
6	Localization
1	Metals/Ions
46	Molecular Weight [Da]
53	Natural Substrates/ Products (Substrates)
257	Organism
12	Pathway
375	PDB ID
23	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
60	Protein Variants
62	Purification (Commentary)
12	Reaction
1	Reaction Type
157	Reference
32	Source Tissue
46	Specific Activity [micromol/min/mg]
13	Storage Stability
153	Substrates and Products (Substrate)
57	Subunits
207	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
73	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 4.3.3.7 - 4-hydroxy-tetrahydrodipicolinate synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

11 entries

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

16 entries

L-aspartate 4-semialdehyde + pyruvate

(S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2O

4 entries

L-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

3 entries

L-aspartate-4-semialdehyde + pyruvate

?

5 entries

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

12 entries

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Caldanaerobacter subterraneus subsp. tengcongensis

Q8RBI5

-

692255

-

-

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Escherichia coli

P0A6L2

-

690252, 695011

-

-

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Escherichia coli

-

-

695011

-

-

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Escherichia coli

P0A6L2

branch point reaction in the biosynthesis of lysine

652939

-

652939

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Escherichia coli

-

first step in the biosynthesis of lysine, overview

649771

-

649771

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Escherichia coli XL1-Blue

-

first step in the biosynthesis of lysine, overview

649771

-

649771

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Staphylococcus aureus

Q5HG25

-

692356

-

-

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Staphylococcus aureus

Q6GH13

-

693141

-

-

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Staphylococcus aureus COL

Q5HG25

-

692356

-

-

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Staphylococcus aureus MRSA252

Q6GH13

-

693141

-

-

?

(S)-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Thermotoga maritima

Q9X1K9

catalyses the branch point in lysine biosynthesis

678046

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Agrobacterium tumefaciens

A9CFV4, A9CGZ4, A9CHR2, A9CL94, A9CL97, Q7CU96, Q7D0E8, Q7D313, Q7D3Z9, Q8UGL3

-

730915

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Agrobacterium tumefaciens

Q8UGL3

-

728891

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Agrobacterium tumefaciens C58 / ATCC 33970

A9CFV4, A9CGZ4, A9CHR2, A9CL94, A9CL97, Q7CU96, Q7D0E8, Q7D313, Q7D3Z9, Q8UGL3

-

730915

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Agrobacterium tumefaciens C58 / ATCC 33970

Q8UGL3

-

728891

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Aquifex aeolicus

O67216

-

729694

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Arabidopsis thaliana

Q9FVC8

-

728886

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Campylobacter jejuni

-

-

729237

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Corynebacterium glutamicum

-

-

729062

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Corynebacterium glutamicum ATCC 13032

-

-

729062

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Escherichia coli

-

-

729062

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Escherichia coli

P0A6L2

-

730908

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Escherichia coli

-

the enzyme-catalyzed reaction is initiated by condensation of pyruvate with an active site Lys161 forming a Schiff base. Subsequent tautomerization to the enamine and aldol-type reaction with (S)-aspartate-4-semialdehyde then generates an acyclic enzyme-bound intermediate. Transimination of the acyclic intermediate yields the cyclic alcohol (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid, with simultaneous release of the active site lysine residue

729385

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Escherichia coli MG1655

-

-

729062

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Legionella pneumophila

-

-

728904

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Pseudomonas aeruginosa

Q9I4W3

-

720852

-

-

?

(S)-aspartate-4-semialdehyde + pyruvate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O

Vitis vinifera

-

-

728889

-

-

?

L-aspartate 4-semialdehyde + pyruvate

(S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2O

Escherichia coli

-

-

712704, 713953

-

-

?

L-aspartate 4-semialdehyde + pyruvate

(S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2O

Mycobacterium tuberculosis

-

-

713969

-

-

?

L-aspartate 4-semialdehyde + pyruvate

(S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2O

Pseudomonas aeruginosa

Q9I4W3

-

715195

-

-

?

L-aspartate 4-semialdehyde + pyruvate

(S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2O

Thermotoga maritima

-

-

714351

-

-

?

L-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Escherichia coli

P0A6L2

-

664072

-

-

?

L-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Sinorhizobium meliloti

Q07607

-

691786

-

-

?

L-aspartate 4-semialdehyde + pyruvate

dihydrodipicolinate + H2O

Sinorhizobium meliloti L5-30

Q07607

-

691786

-

-

?

L-aspartate-4-semialdehyde + pyruvate

?

Escherichia coli

-

synthesis of the precursor of dipicolinic acid which plays a key role in bacterial sporulation process

33912

-

-

?

L-aspartate-4-semialdehyde + pyruvate

?

Geobacillus stearothermophilus

-

first enzyme in the meso-diaminopimelate and L-lysine branch of the aspartate pathway

33914

-

-

?

L-aspartate-4-semialdehyde + pyruvate

?

Spinacia oleracea

-

-

33903

-

-

?

L-aspartate-4-semialdehyde + pyruvate

?

Triticum aestivum

-

biosynthesis of lysine via the diaminopimelate pathway

33902

-

-

?

L-aspartate-4-semialdehyde + pyruvate

?

Zea mays

-

-

33911

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Bacteroides thetaiotaomicron

Q8A3Z0

the enzyme catalyzes a step of the diaminopimelate biosynthetic pathway of lysine

746655

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Bacteroides thetaiotaomicron ATCC 29148

Q8A3Z0

the enzyme catalyzes a step of the diaminopimelate biosynthetic pathway of lysine

746655

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Bartonella henselae

Q6G468

the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis

746659

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Bartonella henselae ATCC 49882

Q6G468

the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis

746659

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Bartonella henselae Houston 1

Q6G468

the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis

746659

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Campylobacter jejuni

-

-

747107, 748035

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Medicago truncatula

-

-

730623

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Medicago truncatula Jemalong 2HA

-

-

730623

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Triticum aestivum

P24846

the enzyme catalyzes the first committed step in the lysine biosynthesis pathway of plants

749039

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Vibrio cholerae

A5F699

the enzyme catalyzes the first committed step in the diaminopimelate pathway

749225

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Vibrio cholerae O395

A5F699

the enzyme catalyzes the first committed step in the diaminopimelate pathway

749225

-

-

?

pyruvate + L-aspartate-4-semialdehyde

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

Vitis vinifera

D7U7T8

-

730624

-

-

?