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4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase

This is an abbreviated version!
For detailed information about 4-hydroxy-tetrahydrodipicolinate synthase, go to the full flat file.

Word Map on EC 4.3.3.7

Reaction

pyruvate
+
L-aspartate-4-semialdehyde
=
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
 +
H2O

Synonyms

Aq_1143, AT2G45440, BA3935 gene product, cDHDPS, CjDHDPS, DapA, DapA2, DHDPA synthase, DHDPS, DHDPS2, dihydro-dipicolinic acid synthase, dihydrodipicolinate synthase, dihydrodipicolinic acid synthase, dihydrodipocolinate synthase, dihydropicolinate synthetase, EC 4.2.1.52, FaDHDPS, HTPA synthase, More, MosA, MosA protein, MRSA-DHDPS, PA1010, pyruvate-aspartic semialdehyde condensing enzyme, Rv2753c, synthase, dihydrodipicolinate, VEG81, Vegetative protein 81

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.3 Amine-lyases
                4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase

IC50 Value

IC50 Value on EC 4.3.3.7 - 4-hydroxy-tetrahydrodipicolinate synthase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
20
(2R,6S)-piperidine-2,6-dicarboxylic acid
Escherichia coli
-
IC50: 20 mM, 83% inhibition at 50 mM
0.065 - 0.068
(S)-lysine
0.0325
2-oxopimelate
Mycobacterium tuberculosis
pH 7.4, 37°C
22
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid
Escherichia coli
-
i.e. chelidamic acid, IC50: 22 mM, 99% inhibition at 50 mM, uncompetitive inhibitor with respect to both substrates
14
dimethyl chelidamate
Escherichia coli
-
IC50: 14 mM. 99% inhibition at 50 mM, noncompetitive with respect to both substrates
20
dipicolinic acid
Escherichia coli
-
IC50: 20 mM, competitive inhibitor
0.033 - 660
L-lysine