4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase

This is an abbreviated version!
For detailed information about 4-hydroxy-tetrahydrodipicolinate synthase, go to the full flat file.

Reaction

Synonyms

Aq_1143, AT2G45440, BA3935 gene product, cDHDPS, CjDHDPS, DapA, DapA2, DHDPA synthase, DHDPS, DHDPS2, dihydro-dipicolinic acid synthase, dihydrodipicolinate synthase, dihydrodipicolinic acid synthase, dihydrodipocolinate synthase, dihydropicolinate synthetase, EC 4.2.1.52, FaDHDPS, HTPA synthase, More, MosA, MosA protein, MRSA-DHDPS, PA1010, pyruvate-aspartic semialdehyde condensing enzyme, Rv2753c, synthase, dihydrodipicolinate, VEG81, Vegetative protein 81

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.3 Amine-lyases

                4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase

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Results	in table
10	Activating Compound
50367	AA Sequence
34	Application
1	CAS Registry Number
67	Cloned(Commentary)
3	Cofactor
52	Crystallization (Commentary)
1	Expression
51	General Information
6	General Stability
13	IC50 Value
219	Inhibitors
28	kcat/KM [mM/s]
53	Ki Value [mM]
140	KM Value [mM]
6	Localization
1	Metals/Ions
46	Molecular Weight [Da]
53	Natural Substrates/ Products (Substrates)
257	Organism
12	Pathway
375	PDB ID
23	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
60	Protein Variants
62	Purification (Commentary)
12	Reaction
1	Reaction Type
157	Reference
32	Source Tissue
46	Specific Activity [micromol/min/mg]
13	Storage Stability
153	Substrates and Products (Substrate)
57	Subunits
207	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
73	Turnover Number [1/s]

General Stability

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General Stability on EC 4.3.3.7 - 4-hydroxy-tetrahydrodipicolinate synthase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

molecular dynamics simulation to analyze the stability of the enzyme

Aquifex aeolicus

O67216

729694

NaCl required for stability, the amount is inversely proportional to the protein concentration

Bacillus licheniformis

-

33910

repeated freezing/thawing causes loss of activity

Escherichia coli

-

33907, 33909

the secondary and quaternary structure is significantly stabilized in the presence of pyruvate

Bacillus anthracis

Q81WN7

704696

unstable at all stages of purification, not stabilized by dithioerythritol, glycerol, KCl, (NH4)2SO4, sucrose, divalent cations

Pisum sativum

-

33915