4.3.3.5: 4'-demethylrebeccamycin synthase

This is an abbreviated version!
For detailed information about 4'-demethylrebeccamycin synthase, go to the full flat file.

Reaction

Synonyms

ngt, RebG

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.3 Amine-lyases

4.3.3.5 4'-demethylrebeccamycin synthase

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Results	in table
188	AA Sequence
1	Cloned(Commentary)
1	General Information
4	Organism
4	Pathway
2	Protein Variants
1	Purification (Commentary)
1	Reaction
4	Reference
10	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 4.3.3.5 - 4'-demethylrebeccamycin synthase

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3-bromo-indolo-[2,3-a]-carbazole + beta-D-glucose

N-(beta-D-glucosyl)-3-bromo-indolo-[2,3-a]-carbazole + H2O

Lentzea aerocolonigenes

80.4% conversion rate

697324

major product is N-glycosylated in position 12, minor product in position 13, ratio of products is 3:1

6-N-methylarcyriaflavin C + beta-D-glucose

13-(beta-D-glucosyl)-6-N-methylarcyriaflavin C

2 entries

carbazole + beta-D-glucose

N-(beta-D-glucosyl)-carbazole + H2O

Lentzea aerocolonigenes

poor substrate

697324

indolo-[2,3-a]-carbazole + beta-D-glucose

N-(beta-D-glucosyl)-indolo-[2,3-a]-carbazole + H2O

Lentzea aerocolonigenes

70.3% conversion rate

697324

J-109303 + beta-D-glucose

J-109384 + H2O

2 entries

rebeccamycin aglycone + beta-D-glucose

rebeccamycin + H2O

Lentzea aerocolonigenes

702730

staurosporine aglycone + beta-D-glucose

N-(beta-D-glucosyl)-staurosporine aglycone + H2O

Lentzea aerocolonigenes

96.4% conversion rate

697324

major product is N-glycosylated in position 12, minor product in position 13, ratio of products is 2:1

additional information

Lentzea aerocolonigenes

remarkable lack of RebG regioselectivity in the presence of asymmetric substrates

697324