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4.3.2.6: gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

This is an abbreviated version!
For detailed information about gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase, go to the full flat file.

Reaction

gamma-L-glutamyl-butirosin B
=
butirosin B
+
5-oxo-L-proline

Synonyms

btrG, gamma-glutamyl cyclotransferase, GGC

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.2 Amidine-lyases
                4.3.2.6 gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

Systematic Name

Systematic Name on EC 4.3.2.6 - gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

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SYSTEMATIC NAME
IUBMB Comments
gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (5-oxoproline producing)
The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the terminal gamma-L-glutamate of the side chain, releasing it as the cyclic 5-oxo-L-proline.