4.3.2.5: peptidylamidoglycolate lyase

This is an abbreviated version!
For detailed information about peptidylamidoglycolate lyase, go to the full flat file.

Word Map on EC 4.3.2.5

4.3.2.5

glycine-extended

monooxygenase

alpha-hydroxylating

ascorbate

neuropeptides

1.14.17.3

entails

alpha-monooxygenase

alpha-ae

peptidyl-alpha-hydroxyglycine

4-phenyl-3-butenoic

dealkylation

prohormones

pro-peptide

ascorbate-dependent

miller

Reaction

Synonyms

alpha-AE, alpha-hydroxyglycine amidating dealkylase, bifunctional peptidylglycine alpha-amidating enzyme, dPAL1 gene product, dPAL2 gene product, HGAD, lyase, peptidyl-alpha hydroxyglycine, PAL, PAL2, peptidyl-alpha-hydroxyglycine alpha-amidating lyase, peptidylamidoglycolate lyase, PGL, rPAL gene product

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.2 Amidine-lyases

4.3.2.5 peptidylamidoglycolate lyase

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Results	in table
4	Activating Compound
1091	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
2	Cofactor
2	General Information
23	Inhibitors
9	Ki Value [mM]
30	KM Value [mM]
12	Localization
13	Metals/Ions
10	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
89	Organism
13	PDB ID
6	pH Optimum
12	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
29	Reference
25	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
36	Substrates and Products (Substrate)
3	Subunits
27	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
6	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.3.2.5 - peptidylamidoglycolate lyase

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(R)-2-phenylbutyl-alpha-hydroxy-Gly

Bos taurus

438592

(S)-2-phenylbutyl-alpha-hydroxy-Gly

2-mercaptoethanol

acetylmethionyl pyruvate

Xenopus laevis

competitive inhibition of PGL domain of full expressed enzyme: AE and monofunctional lyase: PGL

648705

acetylphenylalanyl pyruvate

Xenopus laevis

competitive inhibition of PGL domain of full expressed enzyme: AE and monofunctional lyase: PGL

648705

acetyltyrosyl pyruvate

Xenopus laevis

competitive inhibition of PGL domain of full expressed enzyme: AE and monofunctional lyase: PGL

diethyl dicarbonate

EDTA

EGTA

addition of 0.5-1 M reduces activity to 50%, Ca2+, Mn2+, Co2+ or Ni2+ restore activity

648704

HCl

Rattus norvegicus

0.5 M guanidinium HCl reduces activity to 28%

K2SO4

150 mM

KCl

150 mM

NaCl

150 mM

o-phenanthroline

phenylacetyl-alpha-hydroxy-Gly

Bos taurus

competitive inhibition

Phenylglyoxal

Urea

addition of 1 M urea reduces activity to 58%

648704

additional information

3 entries