4.3.2.4: purine imidazole-ring cyclase

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For detailed information about purine imidazole-ring cyclase, go to the full flat file.

Reaction

Synonyms

cyclase, purine imidazole ring, PurIR cyclase

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.2 Amidine-lyases

                4.3.2.4 purine imidazole-ring cyclase

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181	Organism
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5	pH Range
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1	Reaction
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24	Substrates and Products (Substrate)
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5	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 4.3.2.4 - purine imidazole-ring cyclase

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SYSTEMATIC NAME

IUBMB Comments

DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)

Also acts on 2,6-diamino-5-formamido-3,4-dihydro-4-oxopyrimidine residues. Brings about the reclosure of the imidazole rings of purine residues damaged by gamma-rays.