4.3.2.2: adenylosuccinate lyase

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For detailed information about adenylosuccinate lyase, go to the full flat file.

Reaction

Synonyms

adenylosuccinase, adenylosuccinate lyase, ADL, ADSL, AMPS lyase, ASASE, ASL, Glutamyl-tRNA synthetase regulatory factor, lyase, adenylosuccinate, PurB, succino AMP-lyase, succino-AMP lyase

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.2 Amidine-lyases

                4.3.2.2 adenylosuccinate lyase

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Results	in table
44124	AA Sequence
8	Application
1	CAS Registry Number
22	Cloned(Commentary)
13	Crystallization (Commentary)
462	Disease/ Diagnostics
1	Expression
24	General Information
6	General Stability
74	Inhibitors
9	kcat/KM [mM/s]
3	Ki Value [mM]
72	KM Value [mM]
2	Localization
3	Metals/Ions
72	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
69	Organism
11	Pathway
82	PDB ID
21	pH Optimum
3	pH Range
102	Protein Variants
19	Purification (Commentary)
9	Reaction
10	Reaction Type
69	Reference
29	Source Tissue
69	Specific Activity [micromol/min/mg]
7	Storage Stability
145	Substrates and Products (Substrate)
34	Subunits
52	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
5	Temperature Stability [°C]
12	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 4.3.2.2 - adenylosuccinate lyase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

25

Homo sapiens

-

enzyme is stable for at least 5 days at 25°C, and upon rapid freezing and thawing

682657

37

Homo sapiens

-

t1/2 for enzyme from mutant cell line 1751: 0.23 min, t1/2 for enzyme from mutant cell line 1753: 0.2 min, t1/2 for enzyme from the normal cell lines: 9.65 h

34462

50

Homo sapiens

P30566

at 50°C the wild type enzyme shows 79-84% of the activity at 25°C

708663

60

2 entries

60

Homo sapiens

-

t1/2 for enzyme from mutant cell line 1751: 7.35 h, t1/2 for enzyme from mutant cell line 1753: 6.25 h, t1/2 for enzyme from the normal lines: 2.18 min

34462

60

Homo sapiens

P30566

wild type and mutant enzymes R396H and R396C are relatively stable at 60°C for about 4 h, the R194C mutant enzyme loses most of its activity within about 1 h of incubation at 60 °C

707497