4.3.2.2: adenylosuccinate lyase
This is an abbreviated version!
For detailed information about adenylosuccinate lyase, go to the full flat file.
Word Map on EC 4.3.2.2
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4.3.2.2
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purine
-
saicar
-
succinyladenosine
-
autistic
-
carboxamide
-
psychomotor
-
imp
-
succinylaminoimidazole
-
amylosucrase
-
ribotide
-
geothermalis
-
aminoimidazole
-
drug development
-
medicine
- 4.3.2.2
- purine
-
saicar
-
succinyladenosine
-
autistic
- carboxamide
-
psychomotor
- imp
-
succinylaminoimidazole
- amylosucrase
- ribotide
- geothermalis
-
aminoimidazole
- drug development
- medicine
Reaction
Synonyms
adenylosuccinase, adenylosuccinate lyase, ADL, ADSL, AMPS lyase, ASASE, ASL, Glutamyl-tRNA synthetase regulatory factor, lyase, adenylosuccinate, PurB, succino AMP-lyase, succino-AMP lyase
ECTree
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Subunits
Subunits on EC 4.3.2.2 - adenylosuccinate lyase
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homotetramer
tetramer
homotetramer
recombinant His-tagged wild-type and R303C mutant enzymes, static light scattering
homotetramer
the enzyme forms a tight tetramer with three independent stable interfaces, protomer flexibility and partial disorder. The C3 loop is mostly disordered in subunits B and C, the Mycobacterium smegmatis enzyme is the first reported unliganded enzyme structure in which the C3 loop is ordered at least partially
a homotetramer in which three subunits contribute to each of four active sites, analytical ultracentrifugation, gel filtration, circular dichroism spectroscopy, and interaction analysis, overview. ASL is active and exists as 100% tetramer at 25°C, while at 8°C and 4°C, as hydrophobic interactions are weakened, the catalytic activity decreases strikingly and the enzyme dissociates to a mixture of monomer-dimer-trimer, with small amounts of tetramer. In the presence of increasing concentrations of KBr of 0.12.5 M, which disrupts electrostatic interactions, ASL is dissociated initially to monomerdimer, with small amounts of trimer-tetramer, and then the monomer species predominates along with small amounts of trimer-tetramer, analytical ultracentrifugation, homology modelling of wild-type and mutant enzymes, overview
tetramer
4 * 55000, recombinant His-tagged enzyme, SDS-PAGE, 4 * 56235, recombinant His-tagged enzyme, mass spectrometry
tetramer
4 * 49600, calculated. Enzyme forms a dimer of dimers, crystallization data