4.3.2.2: adenylosuccinate lyase

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For detailed information about adenylosuccinate lyase, go to the full flat file.

Word Map on EC 4.3.2.2

4.3.2.2

purine

saicar

succinyladenosine

autistic

carboxamide

psychomotor

imp

succinylaminoimidazole

amylosucrase

ribotide

geothermalis

aminoimidazole

drug development

medicine

Reaction

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Synonyms

adenylosuccinase, adenylosuccinate lyase, ADL, ADSL, AMPS lyase, ASASE, ASL, Glutamyl-tRNA synthetase regulatory factor, lyase, adenylosuccinate, PurB, succino AMP-lyase, succino-AMP lyase

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.2 Amidine-lyases

4.3.2.2 adenylosuccinate lyase

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Results	in table
44124	AA Sequence
8	Application
1	CAS Registry Number
22	Cloned(Commentary)
13	Crystallization (Commentary)
462	Disease/ Diagnostics
1	Expression
24	General Information
6	General Stability
74	Inhibitors
9	kcat/KM [mM/s]
3	Ki Value [mM]
72	KM Value [mM]
2	Localization
3	Metals/Ions
72	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
69	Organism
11	Pathway
82	PDB ID
21	pH Optimum
3	pH Range
102	Protein Variants
19	Purification (Commentary)
9	Reaction
10	Reaction Type
69	Reference
29	Source Tissue
69	Specific Activity [micromol/min/mg]
7	Storage Stability
145	Substrates and Products (Substrate)
34	Subunits
52	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
5	Temperature Stability [°C]
12	Turnover Number [1/s]

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Application on EC 4.3.2.2 - adenylosuccinate lyase

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drug development

Leishmania braziliensis

A4H3W5

as Leishmania species lack the de novo pathway and are dependent on the salvage pathway to supply their purine requirements, LbASL could thus represent a drug target for the development of chemical agents to treat leishmaniasis

749293

medicine

3 entries

additional information

4 entries