4.3.1.30: dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
This is an abbreviated version!
For detailed information about dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase, go to the full flat file.
Word Map on EC 4.3.1.30
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4.3.1.30
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deamination
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dehydrogenation
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s-adenosyl-l-methionine
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venezuelae
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desosamine
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radical-mediated
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deuterium
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ketone
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deprotonation
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dehydrogenases
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5\'-deoxyadenosyl
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epr
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homolysis
- 4.3.1.30
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deamination
-
dehydrogenation
- s-adenosyl-l-methionine
- venezuelae
-
desosamine
-
radical-mediated
- deuterium
- ketone
-
deprotonation
- dehydrogenases
-
5\'-deoxyadenosyl
- epr
-
homolysis
Reaction
Synonyms
DesII
ECTree
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Cofactor
Cofactor on EC 4.3.1.30 - dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
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a radical S-adenosyl-L-methionine-dependent enzyme. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity
4Fe-4S-center
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[4Fe-4S]1+ is the catalytically active form of all radical S-adenosyl-L-methionine-dependent enzymes. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity
4Fe-4S-center
[4Fe-4S]1+ is the catalytically active form of all radical S-adenosyl-L-methionine-dependent enzymes. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity
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a radical S-adenosyl-L-methionine-dependent enzyme. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity
S-adenosyl-L-methionine
a radical S-adenosyl-L-methionine-dependent enzyme. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity
S-adenosyl-L-methionine
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a radical S-adenosyl-L-methionine-dependent enzyme. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity. Radical S-adenosyl-L-methionine enzymes are an important class of biological catalysts involved in radical mediated transformations in both primary and secondary metabolic pathways. All of these enzymes contain a [4Fe-4S] cluster in the active-site and are S-adenosyl-L-methionine dependent. The reactions are initiated by a single electron transfer from the reduced [4Fe-4S]1+ cluster to SAM to induce the homolytic cleavage of the C5'-S bond in -adenosyl-L-methionine, which yields a reactive 5'-deoxyadenosyl radical along with L-methionine. The 5'-deoxyadenosyl radical is used to generate a substrate radical intermediate that is subsequently converted to product
in the experiment, the [4Fe-4S]2+ of DesII is reduced to [4Fe-4S]1+ by stepwise electron transfer from NADPH through flavodoxin and flavodoxin reductase. Accordingly, a system consisting of flavodoxin/flavodoxin reductase-NADPH or its equivalent from the cellular pool may serve as the in vivo reducing system for the DesII-catalyzed reaction
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additional information
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in the experiment, the [4Fe-4S]2+ of DesII is reduced to [4Fe-4S]1+ by stepwise electron transfer from NADPH through flavodoxin and flavodoxin reductase. Accordingly, a system consisting of flavodoxin/flavodoxin reductase-NADPH or its equivalent from the cellular pool may serve as the in vivo reducing system for the DesII-catalyzed reaction
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