4.3.1.3: histidine ammonia-lyase

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For detailed information about histidine ammonia-lyase, go to the full flat file.

Word Map on EC 4.3.1.3

4.3.1.3

dopamine

antipsychotic

artery

limb

neuroleptic

dopaminergic

clozapine

striatal

gait

robot

rehabilitation

laparoscopic

photodynamic

session

urocanic

cystoscopy

absorptiometry

dyskinesia

schizophrenic

apomorphine

olanzapine

exoskeleton

amphetamine

tardive

urocanase

risperidone

extrapyramidal

isoflurane

catalepsy

dual-energy

homovanillic

wearable

transurethral

aminolevulinate

dehydroalanine

hexyl

cadence

haemophilia

nmibc

supersensitivity

caudate-putamen

white-light

sulpiride

hygienists

quinpirole

robot-assisted

non-muscle-invasive

hemorrhoid

neuroleptic-induced

analysis

synthesis

Reaction

Synonyms

ammonia-lyase, histidine, HAL, HAL1, Hal2, histidase, histidase, Hut, histidinase, histidinase-2, histidine alpha-deaminase, histidine ammonia lyase, histidine ammonia-lyase, histidine ammonia-lyase 2, histidine deaminase, L-HAL, L-histidase, L-histidine NH3-lyase

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.1 Ammonia-lyases

4.3.1.3 histidine ammonia-lyase

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Results	in table
14	Activating Compound
22260	AA Sequence
2	Application
1	CAS Registry Number
13	Cloned(Commentary)
2	Cofactor
6	Crystallization (Commentary)
1083	Disease/ Diagnostics
7	Expression
1	General Stability
153	Inhibitors
21	Ki Value [mM]
41	KM Value [mM]
1	Localization
22	Metals/Ions
29	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
117	Organism
2	Oxidation Stability
8	Pathway
27	PDB ID
11	pH Optimum
8	pH Range
3	Posttranslational Modification
24	Protein Variants
16	Purification (Commentary)
18	Reaction
10	Reaction Type
104	Reference
1	Renatured (Commentary)
55	Source Tissue
46	Specific Activity [micromol/min/mg]
10	Storage Stability
125	Substrates and Products (Substrate)
20	Subunits
37	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.3.1.3 - histidine ammonia-lyase

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L-histidine ammonia-lyase (urocanate-forming)

This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23 (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [4]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [5]. This enzyme catalyses the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate [2,3].