4.3.1.3: histidine ammonia-lyase
This is an abbreviated version!
For detailed information about histidine ammonia-lyase, go to the full flat file.
Word Map on EC 4.3.1.3
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4.3.1.3
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dopamine
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antipsychotic
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artery
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limb
-
neuroleptic
-
dopaminergic
-
clozapine
-
striatal
-
gait
-
robot
-
rehabilitation
-
laparoscopic
-
photodynamic
-
session
-
urocanic
-
cystoscopy
-
absorptiometry
-
dyskinesia
-
schizophrenic
-
apomorphine
-
olanzapine
-
exoskeleton
-
amphetamine
-
tardive
-
urocanase
-
risperidone
-
extrapyramidal
-
isoflurane
-
catalepsy
-
dual-energy
-
homovanillic
-
wearable
-
transurethral
-
aminolevulinate
-
dehydroalanine
-
hexyl
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cadence
-
haemophilia
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nmibc
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supersensitivity
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caudate-putamen
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white-light
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sulpiride
-
hygienists
-
quinpirole
-
robot-assisted
-
non-muscle-invasive
-
hemorrhoid
-
neuroleptic-induced
-
analysis
-
synthesis
- 4.3.1.3
- dopamine
-
antipsychotic
- artery
- limb
-
neuroleptic
-
dopaminergic
- clozapine
- striatal
-
gait
-
robot
-
rehabilitation
-
laparoscopic
-
photodynamic
-
session
-
urocanic
-
cystoscopy
-
absorptiometry
- dyskinesia
-
schizophrenic
- apomorphine
- olanzapine
-
exoskeleton
- amphetamine
-
tardive
- urocanase
- risperidone
-
extrapyramidal
- isoflurane
- catalepsy
-
dual-energy
-
homovanillic
-
wearable
-
transurethral
-
aminolevulinate
- dehydroalanine
-
hexyl
-
cadence
- haemophilia
-
nmibc
-
supersensitivity
-
caudate-putamen
-
white-light
- sulpiride
-
hygienists
- quinpirole
-
robot-assisted
-
non-muscle-invasive
- hemorrhoid
-
neuroleptic-induced
- analysis
- synthesis
Reaction
Synonyms
ammonia-lyase, histidine, HAL, HAL1, Hal2, histidase, histidase, Hut, histidinase, histidinase-2, histidine alpha-deaminase, histidine ammonia lyase, histidine ammonia-lyase, histidine ammonia-lyase 2, histidine deaminase, L-HAL, L-histidase, L-histidine NH3-lyase
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 4.3.1.3 - histidine ammonia-lyase
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additional information
additional information
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the peptide at the active center of the enzyme is considered to be posttranslationally dehydrated to form an electrophilic 4-methylidene-imidazole-one group
additional information
a 3,5-dihydro-5-methylidene-4H-imidazol-4-one electrophilic moiety is post-translationally and autocatalytically generated in homotetrameric histidine ammonia-lyase containing the tripeptide Ala-Ser-Gly in a suitably positioned loop. Dehydration, rather than dehydrogenation by molecular oxygen, is the reaction that gives rise to the mature MIO ring system. Water molecules play a highly relevant role in the reaction mechanism. The backbone cyclization resulting from the nucleophilic attack of the Gly amide lone pair on the pi orbital of the Ala carbonyl precedes side-chain dehydration of the central serine
additional information
-
a 3,5-dihydro-5-methylidene-4H-imidazol-4-one electrophilic moiety is post-translationally and autocatalytically generated in homotetrameric histidine ammonia-lyase containing the tripeptide Ala-Ser-Gly in a suitably positioned loop. Dehydration, rather than dehydrogenation by molecular oxygen, is the reaction that gives rise to the mature MIO ring system. Water molecules play a highly relevant role in the reaction mechanism. The backbone cyclization resulting from the nucleophilic attack of the Gly amide lone pair on the pi orbital of the Ala carbonyl precedes side-chain dehydration of the central serine