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4.3.1.3: histidine ammonia-lyase

This is an abbreviated version!
For detailed information about histidine ammonia-lyase, go to the full flat file.

Word Map on EC 4.3.1.3

Reaction

L-histidine
=
Urocanate
+
NH3

Synonyms

ammonia-lyase, histidine, HAL, HAL1, Hal2, histidase, histidase, Hut, histidinase, histidinase-2, histidine alpha-deaminase, histidine ammonia lyase, histidine ammonia-lyase, histidine ammonia-lyase 2, histidine deaminase, L-HAL, L-histidase, L-histidine NH3-lyase

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.3 histidine ammonia-lyase

Inhibitors

Inhibitors on EC 4.3.1.3 - histidine ammonia-lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-3-(1-benzofuran-2-yl)prop-2-enoic acid
-
-
(2E)-3-(1-benzofuran-3-yl)prop-2-enoic acid
-
-
(2E)-3-(1-benzothiophen-2-yl)prop-2-enoic acid
-
-
(2E)-3-(1-benzothiophen-3-yl)prop-2-enoic acid
-
-
(2E)-3-(1-methyl-1H-indol-3-yl)prop-2-enoic acid
-
-
(2E)-3-(1H-indol-3-yl)prop-2-enoic acid
-
-
(2E)-3-(3-methylfuran-2-yl)prop-2-enoic acid
-
-
(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid
-
-
(2E)-3-furan-2-ylprop-2-enoic acid
-
-
(2E)-3-thiophen-2-ylprop-2-enoic acid
-
-
1,2,4-triazole-DL-alanine
Achromobacter liquidum
-
competitive
1-amino-2-imidazol-4'-ylethylphosphonic acid
-
reversible, competitive, 1 mM: complete inhibition
1-Methyltryptophan
-
-
2,3 butanedione
-
-
2-mercaptoethanol
-
inhibition at concentrations above 10 mM, reversed by addition of metal ion
2-methyl-DL-histidine
Achromobacter liquidum
-
competitive
2-thiazolyl-DL-alanine
Achromobacter liquidum
-
competitive
3-(1-benzofuran-2-yl)alanine
-
-
3-(1-benzofuran-3-yl)alanine
-
-
3-(1-benzothiophen-2-yl)alanine
-
-
3-(1-benzothiophen-3-yl)alanine
-
-
3-(3-methylthiophen-2-yl)alanine
-
-
3-furan-2-ylalanine
-
-
3-methyl-L-histidine
Achromobacter liquidum
-
competitive
3-thiophen-2-ylalanine
-
-
4-nitro-L-histidine
-
competitive
5,5'-dithiobis(2-nitrobenzoic acid)
5-fluoro-L-histidine
8-methoxypsoralen
-
noncompetitive. Irradiation of 8-methoxypsoralen with broadband UVA and broadband UVA/UVB results in uncompetitive inhibition due to psoralen-oxidized photoproducts
all-trans retinoic acid
-
1 microM suppresses histidase expression almost completely, levels of histidase mRNA expression in the presence of all-trans retinoic acid are significantly lower on day 2 of post-confluence and at all later time points during keratinocyte differentiation
alpha-methyl-DL-histidine
Achromobacter liquidum
-
competitive
Ba2+
Achromobacter liquidum
-
1 mM
beta-imidazole lactic acid
Achromobacter liquidum
-
competitive
biguanide
-
-
bisulfite
Co3+
-
0.1 mM, 95% inhibition
Cu2+
-
0.1 mM, 70% inhibition
cyanide
-
50 mM histidinol phosphate, 5 mM L-histidine and 5 mM Mn2+ protects
D-alpha-hydrazinohistidine
-
competitive
D-alpha-hydrazinoimidazolylpropionic acid
D-cysteine
-
in the presence of Cd2+
D-histidine
dithiothreitol
DL-alpha-hydrazinoimidazolylpropionic acid
-
70% irreversible inactivation in vivo
DL-pyrazolyl-3-alanine
-
5.0 mM
Fe2+
-
0.1 mM, 60% inhibition
formyl-L-histidine
Achromobacter liquidum
-
competitive
glycine
H2O2
Achromobacter liquidum
-
-
histidinol phosphate
-
competitive
hydroxylamine
-
-
hydroxymethylimidazole
Achromobacter liquidum
-
competitive
-
imidazol-3-ylpyruvate
-
uncompetitive
imidazole
Achromobacter liquidum
-
noncompetitive
interleukin-1alpha
-
treatment of IL-1a reduces histidase expression, the suppressive effect can be reverted by concomitant treatment with interleukin-1alpha receptor antagonist
-
L-1-methylhistidine
-
5.0 mM
L-alanine
-
5.0 mM
L-alpha-hydrazinoimidazolylpropionic acid
-
competitive
L-cysteine
L-histidine hydrazide
Achromobacter liquidum
-
noncompetitive
L-histidine hydroxamate
L-histidinemethyl ester
L-histidinol
L-homocysteine
-
irreversible in the presence of O2 and high pH
L-N-gamma-methylhistidine
-
weak competitive
L-tyrosine
-
heat-purified enzyme, at low concentrations, pH 7-8
methylglyoxal
-
-
N-acetyl-L-histidine
-
5.0 mM
N-ethylmaleimide
-
1 mM, partial
NaBH4
Nitromethane
norhistidine
-
-
O2
-
irreversible
p-hydroxyphenylpyruvate
-
heat-purified enzyme, at low concentrations, pH 7-8
p-mercuribenzoate
Pb2+
Achromobacter liquidum
-
1 mM
Phenylglyoxal
-
protection by histidinol phosphate
phenylhydrazine
-
-
Sodium diphosphate
-
-
TGF-alpha
-
most pronounced effect, leads to almost complete suppression of histidase expression
-
TNF-alpha
-
suppresses the expression of histidase
-
tryptophan
-
-
Urocanate
additional information
-