4.3.1.3: histidine ammonia-lyase
This is an abbreviated version!
For detailed information about histidine ammonia-lyase, go to the full flat file.
Word Map on EC 4.3.1.3
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4.3.1.3
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dopamine
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antipsychotic
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artery
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limb
-
neuroleptic
-
dopaminergic
-
clozapine
-
striatal
-
gait
-
robot
-
rehabilitation
-
laparoscopic
-
photodynamic
-
session
-
urocanic
-
cystoscopy
-
absorptiometry
-
dyskinesia
-
schizophrenic
-
apomorphine
-
olanzapine
-
exoskeleton
-
amphetamine
-
tardive
-
urocanase
-
risperidone
-
extrapyramidal
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isoflurane
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catalepsy
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dual-energy
-
homovanillic
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wearable
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transurethral
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aminolevulinate
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dehydroalanine
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hexyl
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cadence
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haemophilia
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nmibc
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supersensitivity
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caudate-putamen
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white-light
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sulpiride
-
hygienists
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quinpirole
-
robot-assisted
-
non-muscle-invasive
-
hemorrhoid
-
neuroleptic-induced
-
analysis
-
synthesis
- 4.3.1.3
- dopamine
-
antipsychotic
- artery
- limb
-
neuroleptic
-
dopaminergic
- clozapine
- striatal
-
gait
-
robot
-
rehabilitation
-
laparoscopic
-
photodynamic
-
session
-
urocanic
-
cystoscopy
-
absorptiometry
- dyskinesia
-
schizophrenic
- apomorphine
- olanzapine
-
exoskeleton
- amphetamine
-
tardive
- urocanase
- risperidone
-
extrapyramidal
- isoflurane
- catalepsy
-
dual-energy
-
homovanillic
-
wearable
-
transurethral
-
aminolevulinate
- dehydroalanine
-
hexyl
-
cadence
- haemophilia
-
nmibc
-
supersensitivity
-
caudate-putamen
-
white-light
- sulpiride
-
hygienists
- quinpirole
-
robot-assisted
-
non-muscle-invasive
- hemorrhoid
-
neuroleptic-induced
- analysis
- synthesis
Reaction
Synonyms
ammonia-lyase, histidine, HAL, HAL1, Hal2, histidase, histidase, Hut, histidinase, histidinase-2, histidine alpha-deaminase, histidine ammonia lyase, histidine ammonia-lyase, histidine ammonia-lyase 2, histidine deaminase, L-HAL, L-histidase, L-histidine NH3-lyase
ECTree
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Inhibitors
Inhibitors on EC 4.3.1.3 - histidine ammonia-lyase
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1-amino-2-imidazol-4'-ylethylphosphonic acid
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reversible, competitive, 1 mM: complete inhibition
2-mercaptoethanol
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inhibition at concentrations above 10 mM, reversed by addition of metal ion
8-methoxypsoralen
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noncompetitive. Irradiation of 8-methoxypsoralen with broadband UVA and broadband UVA/UVB results in uncompetitive inhibition due to psoralen-oxidized photoproducts
all-trans retinoic acid
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1 microM suppresses histidase expression almost completely, levels of histidase mRNA expression in the presence of all-trans retinoic acid are significantly lower on day 2 of post-confluence and at all later time points during keratinocyte differentiation
cyanide
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50 mM histidinol phosphate, 5 mM L-histidine and 5 mM Mn2+ protects
DL-alpha-hydrazinoimidazolylpropionic acid
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70% irreversible inactivation in vivo
interleukin-1alpha
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treatment of IL-1a reduces histidase expression, the suppressive effect can be reverted by concomitant treatment with interleukin-1alpha receptor antagonist
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TGF-alpha
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most pronounced effect, leads to almost complete suppression of histidase expression
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5,5'-dithiobis(2-nitrobenzoic acid)
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protection of reduced enzyme by Cd2+ against inactivation
bisulfite
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10 mM, 95% loss of activity after 90 min, 0.1 mM 1-amino-2-imidazol-4'-ylethylphosphoric acid protects
dithiothreitol
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20 mM, liver and epidermal enzyme, restored by addition with Zn2+
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0.02 M glycine buffer, 40% inhibition. Inhibition can be overcome by addition of cations, including Mn2+, Ca2+, and Mg2+
L-cysteine
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10 mM, complete inactivation after 3 h under aerobic conditions
L-cysteine
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50 mM, complete inaction at basic pH in the presence of O2 is due to a covalent modification of the enzyme
L-cysteine
10 mM, complete inactivation at pH higher than 10 in the presence of O2
L-cysteine
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competitive in the presence of EDTA; in the presence of Cd2+; irreversible in the presence of O2
p-mercuribenzoate
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0.01 mM, complete inhibition, partially reversed by addition of histidine