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4.3.1.3: histidine ammonia-lyase

This is an abbreviated version!
For detailed information about histidine ammonia-lyase, go to the full flat file.

Word Map on EC 4.3.1.3

Reaction

L-histidine
=
Urocanate
+
NH3

Synonyms

ammonia-lyase, histidine, HAL, HAL1, Hal2, histidase, histidase, Hut, histidinase, histidinase-2, histidine alpha-deaminase, histidine ammonia lyase, histidine ammonia-lyase, histidine ammonia-lyase 2, histidine deaminase, L-HAL, L-histidase, L-histidine NH3-lyase

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.3 histidine ammonia-lyase

Expression

Expression on EC 4.3.1.3 - histidine ammonia-lyase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
brefeldin A induces expression strongly
HAL2 is highly upregulated by T3
increased expression is observed in Hep-G2 cells treated with Vemurafenib
SU11274 and ATM kinase inhibitor increase expression slightly
the histidine ammonia-lyase-2 gene is strongly and specifically activated by thyroid hormone T3 in the proliferating adult stem cells. A putative T3 response element is detected by bioinformatics analysis in the HAL2 gene which mediates the induction of HAL2 gene by thyroid hormone T3 in the developing adult intestinal stem cells during metamorphosis