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4.3.1.3: histidine ammonia-lyase

This is an abbreviated version!
For detailed information about histidine ammonia-lyase, go to the full flat file.

Word Map on EC 4.3.1.3

Reaction

L-histidine
=
Urocanate
 +
NH3

Synonyms

ammonia-lyase, histidine, HAL, HAL1, Hal2, histidase, histidase, Hut, histidinase, histidinase-2, histidine alpha-deaminase, histidine ammonia lyase, histidine ammonia-lyase, histidine ammonia-lyase 2, histidine deaminase, L-HAL, L-histidase, L-histidine NH3-lyase

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.3 histidine ammonia-lyase

Engineering

Engineering on EC 4.3.1.3 - histidine ammonia-lyase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A142D
3.4% of wild-type activity
A142G
93% of wild-type activity
C273A
20% of wild-type kcat
C273A/D145A
no activity, crystal structure
C273A/E414A
no activity
C273A/E414Q
0.06% of wild-type kcat
C273A/F329A
C273A/F329G
no activity, crystal structure
C273A/H83L
no activity
C273A/N195A
0.02% of wild-type kcat
C273A/Q277A
0.2% of wild-type kcat
C273A/R283I
0.9% of wild-type kcat
C273A/R283K
0.01% of wild-type kcat
C273A/Y280F
0.4% of wild-type kcat
C273A/Y53F
no activity
Cys273A
D145A
no activity
F329A
0.04% of wild-type activity
F329G
no activity
G141A
1.1% of wild-type activity
G144A
37% of wild-type activity
Y280F
0.9% of wild-type activity