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4.3.1.24: phenylalanine ammonia-lyase

This is an abbreviated version!
For detailed information about phenylalanine ammonia-lyase, go to the full flat file.

Word Map on EC 4.3.1.24

Reaction

L-phenylalanine
=
trans-cinnamate
 +
NH3

Synonyms

AtPAL 1, AtPAL 2, AtPAL 3, AtPAL 4, AtPAL-1, AtPAL-2, AtPAL-3, AtPAL-4, AtPAL2, AvPAL, DcPAL1, EC 4.3.1.5, EncP, L-phenylalanine ammonia-lyase, L-phenylalanine-ammonia lyase, LrPAL3, LsPAL1, More, PAL, PAL-CLEA, PAL1, PAL2, PAL3, PAL3a, PAL3b, PAL4, PAL5, PAL6, PALrs1, PcPAL1, Phe ammonia-lyase, phenylalanine ammonia lyase, phenylalanine ammonia-lyase, phenylalanine ammonia-lyase 1, phenylalanine ammonia-lyase 2, phenylalanine ammonia-lyase 3, phenylalanine ammonia-lyase 4, RgPAL, RxPAL, Sb04g026520, SsPAL1, TcPAL, ZmPAL2

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.24 phenylalanine ammonia-lyase

KM Value

KM Value on EC 4.3.1.24 - phenylalanine ammonia-lyase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.07
(2E)-3-(3-fluorophenyl)prop-2-enoic acid
pH 8.3, 30°C
3.3
(2E)-3-(3-hydroxyphenyl)prop-2-enoic acid
pH 8.3, 30°C
0.12
(2E)-3-(4-fluorophenyl)prop-2-enoic acid
pH 8.3, 30°C
0.66
(2E)-3-(4-nitrophenyl)prop-2-enoic acid
pH 8.3, 30°C
0.39
(2E)-3-(pyridin-3-yl)prop-2-enoic acid
pH 8.3, 30°C
0.38
(2E)-3-(pyridin-4-yl)prop-2-enoic acid
pH 8.3, 30°C
0.03
(2E)-3-phenylprop-2-enoic acid
pH 8.3, 30°C
1.51
(2E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoic acid
pH 8.3, 30°C
0.3 - 0.7
(2E)-4-fluoro-cinnamic acid
0.1 - 0.4
(2E)-4-formyl-cinnamic acid
5.9 - 12.6
(2E)-4-hydroxycinnamate
0.1 - 0.5
(2E)-4-methyl-cinnamic acid
2.8 - 4.2
(2E)-4-nitro-cinnamic acid
0.75
(2S)-2-amino-3-(3-fluorophenyl)propanoic acid
pH 8.3, 30°C
1.11
(2S)-2-amino-3-(3-hydroxyphenyl)propanoic acid
pH 8.3, 30°C
0.56
(2S)-2-amino-3-(4-fluorophenyl)propanoic acid
pH 8.3, 30°C
0.23
(2S)-2-amino-3-(4-nitrophenyl)propanoic acid
pH 8.3, 30°C
3.39
(2S)-2-amino-3-(pyridin-3-yl)propanoic acid
pH 8.3, 30°C
0.48
(2S)-2-amino-3-(pyridin-4-yl)propanoic acid
pH 8.3, 30°C
0.29
(2S)-2-amino-3-phenylpropanoic acid
pH 8.3, 30°C
1.05
(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propanoic acid
pH 8.3, 30°C
0.2
(E)-cinnamate
0.076
2,3,4,5,6-pentafluoro-L-phenylalanine
-
-
0.085
2,6-difluoro-L-phenylalanine
-
-
0.048
2-amino-3-(1-benzofuran-2-yl)propanoic acid
-
pH 8.8, 30°C
0.116
2-amino-3-(1-benzothien-2-yl)propanoic acid
-
pH 8.8, 30°C
0.076
2-amino-3-(2-furyl)propanoic acid
-
pH 8.8, 30°C
0.134
2-amino-3-(2-thienyl)propanoic acid
-
pH 8.8, 30°C
0.018
2-amino-3-(3-thienyl)propanoic acid
-
pH 8.8, 30°C
0.05
2-chloro-L-phenylalanine
-
-
0.065
2-fluoro-L-phenylalanine
-
-
0.159
3,5-difluoro-L-phenylalanine
-
-
0.094
3-chloro-L-phenylalanine
-
-
0.079
3-fluoro-L-phenylalanine
-
-
0.045
4-chloro-L-phenylalanine
-
-
0.01 - 0.4
4-fluoro-L-phenylalanine
2 - 2.2
4-nitro-L-phenylalanine
2.5 - 3.1
4-trifluoromethyl-L-phenylalanine
0.0065 - 75.6
L-Phe
0.022 - 42.4
L-phenylalanine
16
L-propargylglycine
-
pH 8.8, 30°C
0.186 - 4.384
L-styrylalanine
0.097 - 7.8
L-Tyr
0.4 - 2.4
L-tyrosine
6.6
N-methyl-L-phenylalanine
-
-
2.6 - 4.4
NH3
0.05
phenylalanine
-
C503S/C565S mutant PAL
0.0783 - 0.154
rac-(E)-2-amino-5-(4-chlorophenyl)pent-4-enoic acid
0.201 - 0.395
rac-(E)-2-amino-5-phenylpent-4-enoic acid
0.05
trans-cinnamate
additional information
L-phenylalanine