4.3.1.23: tyrosine ammonia-lyase

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For detailed information about tyrosine ammonia-lyase, go to the full flat file.

Word Map on EC 4.3.1.23

4.3.1.23

p-coumaric

4-coumarate

glutinis

saccharothrix

p-hydroxycinnamic

trans-cinnamic

phcas

4-coumarate:coa

4.3.1.5

synthesis

agriculture

Reaction

Synonyms

EC 4.3.1.5, rsTAL, TAL, tyrosine ammonia lyase, tyrosine ammonia-lyase

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.1 Ammonia-lyases

4.3.1.23 tyrosine ammonia-lyase

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8	Metals/Ions
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17	Organism
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Systematic Name on EC 4.3.1.23 - tyrosine ammonia-lyase

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L-tyrosine ammonia-lyase (trans-p-hydroxycinnamate-forming)

This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [1]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [3]. The enzyme is far more active with tyrosine than with phenylalanine as substrate, but the substrate specificity can be switched by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides [1,2].