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4.3.1.2: methylaspartate ammonia-lyase

This is an abbreviated version!
For detailed information about methylaspartate ammonia-lyase, go to the full flat file.

Word Map on EC 4.3.1.2

Reaction

L-threo-3-methylaspartate
=
mesaconate
+
NH3

Synonyms

3-methyl-L-aspartic acid ammonia-lyase, 3-methylaspartase, 3-methylaspartate ammonia lyase, 3-methylaspartate ammonia-lyase, ammonia-lyase, methylaspartate, beta-methylaspartase, Ch-MAL, MAL, methylaspartate ammonia lyase, methylaspartate ammonia-lyase, threo-3-methyl-L-aspartate ammonia-lyase, threo-3-methylaspartase ammonia-lyase

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.2 methylaspartate ammonia-lyase

Inhibitors

Inhibitors on EC 4.3.1.2 - methylaspartate ammonia-lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,2'-dipyridyl
-
70% loss of activity in the deamination reaction of L-threo-3-methylaspartate
3-bromoaspartate
-
irreversible
4-nitrophenylhydrazine
-
90% inhibition after 200 min
5,5'-dithiobis(2-nitrobenzoate)
8-hydroxyquinoline
Al3+
-
5 mM AlCl3, 95% loss of activity
hydroxylamine
-
-
iodoacetate
-
1 mM, 86% loss of activity
methylhydrazine
-
-
N-ethylmaleimide
o-phenanthroline
-
24% loss of activity in the deamination reaction of L-threo-3-methylaspartate
p-chloromercuribenzoate
p-mercuribenzoate
-
-
Pb2+
-
5 mM PbCl2, 88% loss of activity
phenylhydrazine
Sr2+
-
competitive inhibition of Mg2+ activation of the enzyme
Zn2+
-
30% loss of activity in the deamination reaction of L-threo-3-methylaspartate
additional information
-