4.3.1.18: D-Serine ammonia-lyase
This is an abbreviated version!
For detailed information about D-Serine ammonia-lyase, go to the full flat file.
Word Map on EC 4.3.1.18
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4.3.1.18
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5'-phosphate
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l-serine
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d-threonine
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tryptophanase
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coagonists
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fold-type
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5'-phosphate-dependent
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pyridoxal-p
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merodiploids
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medicine
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pharmacology
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analysis
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molecular biology
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degradation
- 4.3.1.18
- 5'-phosphate
- l-serine
- d-threonine
- tryptophanase
-
coagonists
-
fold-type
-
5'-phosphate-dependent
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pyridoxal-p
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merodiploids
- medicine
- pharmacology
- analysis
- molecular biology
- degradation
Reaction
Synonyms
chDSD, D-Hydroxy amino acid dehydratase, D-Ser dehydratase, D-serine ammonia lyase, D-serine ammonia-lyase, D-Serine deaminase, D-Serine dehydrase, D-serine dehydratase, D-Serine hydrolase (deaminating), DDB_G0289463, Dehydratase, D-serine, DSD, Dsd1p, DsdA, Dsdase, DsdSC, EC 4.2.1.14, PA3357, PH0054, Serine deaminase
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Reaction
Reaction on EC 4.3.1.18 - D-Serine ammonia-lyase
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reaction mechanism, the phosphate group of the substrate-pyridoxal-phosphate complex serves as the main anchoring point during catalysis, intermediate is the Schiff base of alpha-aminoacrylate and pyridoxal 5'-phosphate
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D-Serine = pyruvate + NH3
transimination of the enzyme-linked cofactor pyridoxal 5'-phosphate is at least a two-step process, the first step of which is probably formation of a noncovalent complex between the enzyme and the amino acid
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D-Serine = pyruvate + NH3
A pyridoxal-phosphate protein. Also acts, slowly, on D-threonine. The reaction catalysed probably involves initial elimination of water, hence the enzyme's original classification as EC 4.2.1.14, D-serine dehydratase, followed by isomerization and hydrolysis of the product with C-N bond breakage
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