4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

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For detailed information about 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, go to the full flat file.

Reaction

Synonyms

(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, EC 2.5.1.64, MenH, SHCHC, SHCHC synthase, YfbB

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.99 Other carbon-oxygen lyases

                4.2.99.20 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

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Results	in table
6542	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
3	Crystallization (Commentary)
1	General Information
24	kcat/KM [mM/s]
29	KM Value [mM]
1	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
6	Organism
6	Pathway
17	PDB ID
1	pH Optimum
25	Protein Variants
3	Purification (Commentary)
2	Reaction
1	Reaction Type
6	Reference
7	Substrates and Products (Substrate)
2	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
24	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.99.20 - 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

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SYSTEMATIC NAME

IUBMB Comments

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate pyruvate-lyase [(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate-forming]

This enzyme is involved in the biosynthesis of vitamin K2 (menaquinone). In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase, were carried out by a single enzyme but this has since been disproved [2].