4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase

This is an abbreviated version!
For detailed information about DNA-(apurinic or apyrimidinic site) lyase, go to the full flat file.

Word Map on EC 4.2.99.18

4.2.99.18

strand

exonuclease

glycosylases

single-stranded

pyrimidine

endonucleases

8-oxoguanine

nick

thymine

uracil

duplex

genotoxic

xrcc1

phosphodiester

comet

deoxyribose

methanesulfonate

mispairs

uracil-dna

depurinated

beta-elimination

excise

formamidopyrimidine

3'-phosphatase

7,8-dihydro-8-oxoguanine

tetrahydrofuran

site-containing

mutyh

endonucleolytic

xeroderma

pigmentosum

base-excision

3'-phosphodiesterase

cross-complementing

8-oxo-7,8-dihydroguanine

fen1

unrepaired

formamidopyrimidine-dna

incises

long-patch

dna-repair

uracil-containing

ser326cys

dihydrouracil

arg399gln

3'-exonuclease

reduction-oxidation

enzyme-dna

medicine

gap-filling

damage-specific

analysis

diagnostics

biotechnology

drug development

pharmacology

Reaction

the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate =

Synonyms

8-oxoG DNA glycosylase, abasic (AP)-endonuclease, abasic endonuclease, AdAPE1/Ref-1, Af0371, Afogg enzyme, ALKBH1, AP 1, AP DNA endonuclease 1, AP Dnase, AP endo, AP endonuclease, AP endonuclease 1, AP endonuclease Ape1, AP endonuclease Class I, AP endonuclease I, AP endonuclease VI, AP lyase, AP site-DNA 5'-phosphomonoester-lyase, AP-endonuclease, AP-endonuclease 1, AP-endonuclease 2, AP-endonuclease/3'-5'exodeoxyribonuclease, AP-lyase, Ap1, Ap2, Ape, APE-1, APE/Ref-1, APE1, APE1/Ref-1, Ape1L, Ape2, APEN, APEX nuclease, APEX1, APLM, APN, APN-1, APN1, apurinic DNA endonuclease, apurinic endodeoxyribonuclease, apurinic endonuclease, apurinic endonuclease 1, apurinic-apyrimidinic DNA endonuclease, apurinic-apyrimidinic endodeoxyribonuclease, apurinic-apyrimidinic endonuclease, apurinic-apyrimidinic endonuclease 1, apurinic-apyrimidinic endonuclease I, apurinic/apyrimidic endonuclease 1, apurinic/Apyrimidinic (AP) endonuclease 1, apurinic/apyrimidinic AP endonuclease, apurinic/apyrimidinic DNA endonuclease 1, apurinic/apyrimidinic endonuclease, apurinic/apyrimidinic endonuclease 1, apurinic/apyrimidinic endonuclease 1/redox factor-1, apurinic/apyrimidinic endonuclease 2, apurinic/apyrimidinic endonuclease APE1, apurinic/apyrimidinic endonuclease-1, apurinic/apyrimidinic endonuclease-1/Redox factor-1, apurinic/apyrimidinic endonuclease/redox effector factor-1, Apurinic/apyrimidinic endonuclease1/redox factor 1, apurinic/apyrimidinic endonuclease1/redox factor-1, apurinic/apyrimidinic lyase, apurinic/apyrimidinic site lyase, apurinic/apyrimidinic specific endonuclease, apurinic/apyrimidinic-endonuclease, apyrimidinic endonuclease, archaeal GO glycosylase, BAP1, class II AP endonuclease LMAP, class II apurinic/apyrimidinic(AP)-endonuclease, class-II AP-endonuclease, deoxyribonuclease (apurinic or apyrimidinic), DNA lyase, DNA polymerase X, DNA-(apurinic or apyrimidinic site) lyase, E. coli endonuclease III, EC 3.1.25.2, EcoNth, Endo III, endodeoxyribonuclease, endodeoxyribonuclease III, EndoIV, endonuclease III, endonuclease IV, endonuclease VI, endonuclease VIII, Escherichia coli endonuclease III, EXO-3, ExoA, ExoA type AP endonuclease, ExoIII, HAP-1, HAP1, HAP1h, hAPE, hAPE1, hNTH, hNTH1, hOgg1 protein, HpXth, human apurinic/apyrimidinic endonuclease, human apurinic/apyrimidinic endonuclease 1, Kae1, KsgA, LplExo, Micrococcus luteus UV endonuclease, MJ0724, mjOgg, MMH, More, mtAPE, MtbXthA, multi-functional apyrimidinic endonuclease1/redox factor-1, N-glycosylase AP lyase, N-glycosylase apurinic/apyrimidinic lyase, NapE, Nei, Nfo, Ntg1, Ntg1p, Ntg2, Ntg2p, Nth, NTH1, nuclease SmnA, nuclease, apurinic endodeoxyribo-, nuclease, apurinic-apyrimidinic endodeoxyribo-, nuclease, endodeoxyribo-, III, Ogg2, oxoG DNA glycosylase, Pa-AGOG, Pa-AGOG DNA glycosylase, PAE2237, PaKae1, PALF, pE296R, PF0258, phage-T4 UV endonuclease, redox effector factor 1, redox factor-1, redox factor-1:Ref-1, Ref-1, REF-1 protein, Ref1, SisExoIII, Smx nuclease, TvoExo, UL30, UV endo V, UV endonuclease, UV endonuclease V, X-ray endonuclease III, XTH, xthA, ZAP1, zApe

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.99 Other carbon-oxygen lyases

4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase

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Results	in table
34	Activating Compound
96969	AA Sequence
31	Application
2	CAS Registry Number
89	Cloned(Commentary)
16	Crystallization (Commentary)
2167	Disease/ Diagnostics
6	Expression
98	General Information
5	General Stability
118	IC50 Value
386	Inhibitors
8	kcat/KM [mM/s]
91	Ki Value [mM]
164	KM Value [mM]
85	Localization
171	Metals/Ions
83	Molecular Weight [Da]
219	Natural Substrates/ Products (Substrates)
308	Organism
419	PDB ID
88	pH Optimum
15	pH Range
1	pH Stability
6	pI Value
23	Posttranslational Modification
197	Protein Variants
101	Purification (Commentary)
10	Reaction
44	Reaction Type
261	Reference
147	Source Tissue
79	Specific Activity [micromol/min/mg]
6	Storage Stability
533	Substrates and Products (Substrate)
40	Subunits
434	Synonyms
1	Systematic Name
55	Temperature Optimum [°C]
9	Temperature Range [°C]
21	Temperature Stability [°C]
127	Turnover Number [1/s]

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Source Tissue on EC 4.2.99.18 - DNA-(apurinic or apyrimidinic site) lyase

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B-lymphocyte cell line

Mus musculus

primary cell line, murine B-cells are isolated from spleen by a negative depletion

694203

brain