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4.2.3.B17: (+)-2-epi-prezizaene synthase

This is an abbreviated version!
For detailed information about (+)-2-epi-prezizaene synthase, go to the full flat file.

Reaction

(2Z,6E)-farnesyl diphosphate
=
(+)-2-epi-prezizaene
+
diphosphate

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.B17 (+)-2-epi-prezizaene synthase

Crystallization

Crystallization on EC 4.2.3.B17 - (+)-2-epi-prezizaene synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop method, crystallographic analyses of wild-type enzyme and a promiscuous mutant, with unreactive 2-fluoro analogues ((2E,6E)-2-fluorofarnesyl diphosphate and (2Z,6E)-2-fluorofarnesyl diphosphate) of (2E,6E)- and (2Z,6E)-farnesyl diphosphate reveals catalytically relevant binding modes and distinct farnesyl chain topologies that are consistent with preorganization by the active-site for cisoid or transoid cyclization
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