4.2.3.B17: (+)-2-epi-prezizaene synthase
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Reaction
ECTree
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Crystallization
Crystallization on EC 4.2.3.B17 - (+)-2-epi-prezizaene synthase
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hanging drop method, crystallographic analyses of wild-type enzyme and a promiscuous mutant, with unreactive 2-fluoro analogues ((2E,6E)-2-fluorofarnesyl diphosphate and (2Z,6E)-2-fluorofarnesyl diphosphate) of (2E,6E)- and (2Z,6E)-farnesyl diphosphate reveals catalytically relevant binding modes and distinct farnesyl chain topologies that are consistent with preorganization by the active-site for cisoid or transoid cyclization
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